Clusters of Circulating let-7 Family Tumor Suppressors Are Associated with Clinical Characteristics of Chronic Hepatitis C.

International Journal of Molecular Sciences
Yi-Shan TsaiMing-Lung Yu

Abstract

Hepatitis C virus (HCV) infections can cause permanent liver-related diseases, including hepatocellular carcinoma (HCC). Low mortality and incidence of HCC have been observed in patients with chronic hepatitis C undergoing direct-acting antiviral therapy. Tumor suppressive let-7 family members are down-regulated in HCC. The present study, therefore, aimed to investigate whether expression levels for the full spectrum of let-7 family members (let-7a, 7b, 7c, 7d, 7e, 7f, 7g, 7i, and miR-98) in the circulatory system are useful as surveillance biomarkers for liver-related diseases to monitor treatment efficacy during HCV infection. To this end, we measured the levels of mature circulating let-7 family members using quantitative reverse transcription-PCR in 236 patients with HCV infection, and 147 age- and sex-matched controls. Using hierarchical cluster analysis and principal component analysis, three clusters were obtained after measuring expression levels of let-7 family members in the patients and controls. Cluster 1 included let-7a/d/e/g, Cluster 2 comprised let-7b and let-7i, and Cluster 3 comprised let-7c/f/miR-98. Let-7b/c/g represented the three clusters and showed the best survival response to liver cancer when analyzed w...Continue Reading

References

Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Sep 9, 2008·Trends in Cell Biology·Sarah Roush, Frank J Slack
Sep 26, 2009·Endocrine-related Cancer·Benjamin BoyerinasMarcus E Peter
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hila BarashRinat Abramovitch
Apr 24, 2010·Seminars in Thrombosis and Hemostasis·Ton Lisman, Robert J Porte
Aug 2, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Johannes VermehrenChristoph Sarrazin
Sep 13, 2011·PloS One·Michaela B KirschnerGlen Reid
Dec 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Umberto Vespasiani-GentilucciSergio Morini
Mar 7, 2012·Cellular and Molecular Life Sciences : CMLS·Ju-Chien ChengHsien-Da Huang
May 16, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanjay SwaminathanAnthony D Kelleher
Jul 20, 2012·The Journal of Infectious Diseases·Mei-Hsuan LeeUNKNOWN R.E.V.E.A.L.-HCV Study Group
Jun 8, 2013·Frontiers in Genetics·Michaela B KirschnerGlen Reid
Oct 13, 2014·Journal of Hepatology·Christoph Roderburg, Tom Luedde
Oct 31, 2014·The Journal of Infectious Diseases·Emanuel NiesenRobert Thimme
Dec 3, 2014·Journal of Hepatology·Yujin HoshidaRaymond T Chung
Oct 23, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wen-Wen ChouChia-Yen Dai
May 27, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kentaro MatsuuraHarvey J Alter
Mar 16, 2017·BMC Medicine·Thomas F BaumertYujin Hoshida
Oct 14, 2017·Bioinformatics·Nathan W WongXiaowei Wang
May 24, 2020·Nature Biotechnology·Mary J GoldmanDavid Haussler

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Citations

Aug 10, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Matteo CanaleAndrea Casadei-Gardini

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Methods Mentioned

BETA
PCA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad Prism
JMP
OncomiR

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