cMRI-BED: A novel informatics framework for cardiac MRI biomarker extraction and discovery applied to pediatric cardiomyopathy classification

Biomedical Engineering Online
Vanathi GopalakrishnanShobhit Madan

Abstract

Pediatric cardiomyopathies are a rare, yet heterogeneous group of pathologies of the myocardium that are routinely examined clinically using Cardiovascular Magnetic Resonance Imaging (cMRI). This gold standard powerful non-invasive tool yields high resolution temporal images that characterize myocardial tissue. The complexities associated with the annotation of images and extraction of markers, necessitate the development of efficient workflows to acquire, manage and transform this data into actionable knowledge for patient care to reduce mortality and morbidity. We develop and test a novel informatics framework called cMRI-BED for biomarker extraction and discovery from such complex pediatric cMRI data that includes the use of a suite of tools for image processing, marker extraction and predictive modeling. We applied our workflow to obtain and analyze a dataset of 83 de-identified cases and controls containing cMRI-derived biomarkers for classifying positive versus negative findings of cardiomyopathy in children. Bayesian rule learning (BRL) methods were applied to derive understandable models in the form of propositional rules with posterior probabilities pertaining to their validity. Popular machine learning methods in the ...Continue Reading

References

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Jan 19, 2010·Bioinformatics·Vanathi GopalakrishnanGregory F Cooper
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Citations

Sep 4, 2015·Biomedical Engineering Online·Franscisco M OrtuñoIgnacio Rojas
Sep 16, 2017·Circulation Research·Teresa M LeeSteven E Lipshultz
Feb 6, 2020·The British Journal of Radiology·Beibei JiangXueqian Xie
Feb 11, 2020·Frontiers in Cardiovascular Medicine·Carlos Martin-IslaKarim Lekadir
Dec 10, 2017·Letters in Applied Microbiology·O HerráezM A Galán
Dec 7, 2020·Forensic Science International : Synergy·Rasool EsmaeilyfardSonia Dokohaki
May 6, 2019·Computers in Biology and Medicine·Zhenwei Zhang, Ervin Sejdić

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Software Mentioned

ReportCARDTM
cMRI
WEKA
- BED ( Biomarker Extraction and Discovery )
BED

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