CMV antibody prevalence and seroincidence in plateletpheresis donors

Journal of Clinical Apheresis
Caroline E BoekeJ Brooks Jackson

Abstract

To determine the prevalence and seroincidence of CMV seropositivity in plateletpheresis donors of different ages and gender. CMV antibody serostatus, birthdate, and date of first and most recent donation between the years 1976 and 2006 were retrieved from 222 plateletpheresis donor records at the Johns Hopkins Hospital Donor Center. CMV antibody serostatus was obtained for 183 donors at the most recent donation for which CMV antibody data were available. CMV antibody status and time interval between first and most recent donation were also obtained from 97 repeat plateletpheresis donors who were CMV antibody negative at time of first donation. Overall CMV antibody positivity was 35.5% for 183 donors (mean age = 46.0 years) at time of most recent donation. CMV seropositivity tended to increase with age, being 37.5, 17.9, 37.5, 39.0, and 61.5% for donors aged 20-29 years (n = 8), 30-39 years (n = 39), 40-49 years (n = 64), 50-59 years (n = 59), and 60+ years (n = 13), respectively. Overall CMV seroincidence was 1.6 seroconversions per 100 person years with a rate of 1.4 seroconversions per 100 years for men and 2.3 for women. CMV seroprevalence and seroincidence in this plateletpheresis donor population are relatively low so that...Continue Reading

References

Jan 1, 1991·Transfusion Medicine Reviews·J K Preiksaitis
Sep 1, 1990·Reviews of Infectious Diseases·R H Rubin
Jun 1, 1989·The Journal of Infectious Diseases·N H WhiteS Pokorny
Feb 10, 1968·The Medical Journal of Australia·I Jack, K C McAuliffe
Oct 20, 1983·The New England Journal of Medicine·M E DworskyS Stagno
Nov 1, 1983·Reviews of Infectious Diseases·S P Adler
Jul 19, 2002·Reviews in Medical Virology·John D Roback
Jun 2, 2005·Indian Journal of Medical Microbiology· SheevaniA Aggarwal
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephanie A S StarasMichael J Cannon
Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Manish PatelMichael Schwartz

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Citations

Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David OrlikowskiElyanne Gault
Sep 28, 2010·Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria·D Campany HerreroJ Monterde Junyent
Feb 21, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R A Fisher
Mar 27, 2009·Experimental Dermatology·F BallangerB Dreno
Dec 25, 2010·Journal of Medical Virology·Sócrates Bezerra de MatosFernanda Washington de Mendonça Lima
Jun 22, 2010·Reviews in Medical Virology·Michael J CannonTerri B Hyde
Dec 12, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J McGeeR Zhang
Jul 31, 2013·Pediatric Transplantation·Hidde JongsmaKarlien Cransberg
Jul 21, 2010·Reviews in Medical Virology·Terri B HydeMichael J Cannon
Sep 8, 2010·Journal of Neuro-oncology·Kenneth G LucasCharles Specht

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