PMID: 8601222Apr 1, 1996Paper

CMV-antigenemia in peripheral blood for the diagnosis of CMV disease in HIV-infected patients

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
B SalzbergerM Schrappe

Abstract

In a prospective study of HIV patients with suspected cytomegalovirus (CMV) disease (n = 144; 140 men, four women; aged 23-69 years, median 38 years; CD4 cells 0-400, median 20/microliters), 242 blood samples were examined for the presence of CMV-pp65 antigen in peripheral blood polymorphonuclear leucocytes by use of monoclonal antibodies and alkaline phosphatase-anti-alkaline phosphatase staining. All patients were thoroughly examined for existing CMV disease at first visit and during follow-up (at least 2 months or until death: 0-24 months, median 14 months). In 43/486 samples of patients with CMV disease, the antigen-test was positive and in 179/194 samples of patients without CMV disease the test was negative, resulting in a sensitivity of 90% and a specificity of 93% for the presence of CMV disease in HIV-infected patients.

References

Jul 9, 1988·Lancet·M S WilkesW G Thompson

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Citations

Jan 12, 1999·Disease-a-month : DM·H W HorowitzG P Wormser
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S WalmsleyT Mazzulli
May 20, 1999·The American Journal of the Medical Sciences·D J Skiest
Dec 24, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L G San MiguelA Guerrero
Nov 4, 2000·Expert Opinion on Investigational Drugs·V F Hoffman, D J Skiest
Jun 26, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M DegréK P Nordal
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·D PodzamczerF Gudiol
Jul 17, 1998·Clinical Microbiology Reviews·M Boeckh, G Boivin

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