Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sonia Girard AdamFrancesco Colucci

Abstract

CMV can cause life-threatening disease in immunodeficient hosts. Experimental infection in mice has revealed that the genetically determined natural resistance to murine CMV (MCMV) may be mediated either by direct recognition between the NK receptor Ly49H and the pathogen-encoded glycoprotein m157 or by epistatic interaction between Ly49P and the host MHC H-2D(k). Using stocks of wild-derived inbred mice as a source of genetic diversity, we found that PWK/Pas (PWK) mice were naturally resistant to MCMV. Depletion of NK cells subverted the resistance. Analysis of backcrosses to susceptible BALB/c mice revealed that the phenotype was controlled by a major dominant locus effect linked to the NK gene complex. Haplotype analysis of 41 polymorphic markers in the Ly49h region suggested that PWK mice may share a common ancestral origin with C57BL/6 mice; in the latter, MCMV resistance is dependent on Ly49H-m157 interactions. Nevertheless, PWK mice retained viral resistance against m157-defective mutant MCMV. These results demonstrate the presence of yet another NK cell-dependent viral resistance mechanism, named Cmv4, which most likely encodes for a new NK activating receptor. Identification of Cmv4 will expand our understanding of the...Continue Reading

References

May 1, 1990·The Journal of Experimental Medicine·A A ScalzoG R Shellam
Apr 1, 1981·Infection and Immunity·J E GrundyN F Stanley
Dec 15, 1996·Journal of Immunological Methods·S EhlR Zinkernagel
Jun 12, 1998·The New England Journal of Medicine·J A Fishman, R H Rubin
Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Aug 22, 2001·Immunological Reviews·S K AndersonD W McVicar
May 22, 2002·Nature Immunology·Astrid KrmpotićStipan Jonjić
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hamish R C SmithWayne M Yokoyama
Jul 23, 2002·Nature Genetics·Maureen P MartinMary Carrington
Aug 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tomoji MashimoPhilippe Despres
Sep 3, 2002·Nature Immunology·Francesco ColucciPaul J Leibson
Dec 21, 2002·Trends in Genetics : TIG·Jean Louis Guénet, François Bonhomme
Jan 18, 2003·Immunity·Kouetsu OgasawaraLewis L Lanier
Mar 21, 2003·European Journal of Pediatrics·Michael A GaytantBen A Semmekrot
Apr 2, 2003·Nature Reviews. Immunology·Wayne M Yokoyama, Beatrice F M Plougastel
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Valentina VoigtAnthony A Scalzo
Nov 19, 2003·Microbes and Infection·Astrid KrmpoticStipan Jonjic
Feb 19, 2004·European Journal of Immunology·John Trowsdale, Peter Parham
Jun 29, 2004·Journal of Virology·Ivan BubićUlrich H Koszinowski
Aug 12, 2004·Blood·Mónica GumáMiguel López-Botet
Oct 13, 2004·The Journal of Experimental Medicine·Susan E HibyAshley Moffett
Nov 30, 2004·The Lancet Infectious Diseases·Maher K Gandhi, Rajiv Khanna
Dec 21, 2004·Nature Reviews. Microbiology·Melissa B Lodoen, Lewis L Lanier
Jan 18, 2005·Current Opinion in Immunology·Bruce BeutlerPhilippe Georgel

❮ Previous
Next ❯

Citations

Dec 6, 2006·Immunology and Cell Biology·Anthony A ScalzoMariapia A Degli-Esposti
Oct 24, 2007·Annual Review of Immunology·S M VidalP Gros
Jun 11, 2011·Journal of Biomedicine & Biotechnology·Michal PyzikSilvia M Vidal
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xuefang XieMichael G Brown
Dec 1, 2009·Viruses·Karine Crozat, Philippe Georgel
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aja H DavisJonathan W Heusel
Feb 9, 2008·Medical Microbiology and Immunology·Tihana LenacStipan Jonjić
Mar 15, 2008·Nature Reviews. Immunology·Lewis L Lanier
Dec 5, 2008·Expert Review of Anti-infective Therapy·Nicolas ZucchiniMarc Dalod
Dec 12, 2018·Immunogenetics·Linn E KnutsenPreben Boysen
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nassima Fodil-CornuSilvia M Vidal
Aug 1, 2008·Immunogenetics·Tammy P ChengWayne M Yokoyama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2022 Meta ULC. All rights reserved