CMY-20, a novel AmpC-type beta-lactamase from South African clinical Escherichia coli isolates

Diagnostic Microbiology and Infectious Disease
Chunderika MocktarS Y Essack

Abstract

In this study, we report the presence of a novel plasmid-mediated AmpC-type beta-lactamase that was isolated from 3 clinical Escherichia coli isolates at a tertiary teaching hospital in Durban, South Africa. The nucleotide sequence of the genes encoding this novel beta-lactamase was found to be >94% identical to the nucleotide sequences of the plasmid-mediated AmpC-type beta-lactamases originating from Citrobacter freundii. This enzyme differed from CMY-2 by 3 amino acid substitutions and was designated CMY-20.

References

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Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Alain PhilipponGeorge A Jacoby
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Citations

Jun 3, 2008·Diagnostic Microbiology and Infectious Disease·Govinden UshaEssack Sabiha Yusuf
Oct 14, 2008·Expert Review of Anti-infective Therapy·Johann D D Pitout

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