CNBP regulates forebrain formation at organogenesis stage in chick embryos

Developmental Biology
Yoko AbeYi-Ping Li

Abstract

We recently demonstrated that Cellular Nucleic acid Binding Protein (CNBP)(-/-) mouse embryos exhibit forebrain truncation due to a lack of proper morphogenetic movements of the anterior visceral endoderm (AVE) during pre-gastrulation stage (Chen, W., Liang, Y., Deng, W., Shimizu, K., Ashique, A.M., Li, E., Li, Y.P., 2003. The zinc-finger protein CNBP is required for forebrain formation in the mouse, Development 130, 1367-1379). However, CNBP expression pattern in the mouse forebrain suggests that CNBP may have more direct effects during forebrain development. Our data show that CNBP is expressed in tissues of early chick embryo that are the equivalent to the mouse embryo. Using a combination of RNAi-silencing and Retrovirus-misexpression approaches, we investigated the temporal function of CNBP in the specification/development of the chick forebrain during organogenesis. The silencing of CNBP expression resulted in forebrain truncation and the absence of BF-1, Six3 and Hesx1 expression, but not Otx2 in chick embryos. Misexpression of CNBP induced the expression of BF-1, Six3 and Hesx1 in the hindbrain, but not the expression of Otx2. These results offer novel insights into the function of CNBP during organogenesis as the regul...Continue Reading

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Citations

Feb 1, 2011·Biochemical and Biophysical Research Communications·Morgan A SammonsAndrew J Link
Jul 14, 2010·Neuroscience Letters·Dana M NiedowiczM Paul Murphy
Oct 18, 2011·Development, Growth & Differentiation·Andrea M J WeinerNora B Calcaterra
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Aug 26, 2014·Biochimica Et Biophysica Acta·Ezequiel MargaritNora B Calcaterra
Jul 10, 2020·Clinical Oral Investigations·C DubucsJulie Plaisancié
Jul 25, 2017·Scientific Reports·Maryam AnwarAndrea Streit
May 16, 2019·Molecular Carcinogenesis·Eunhye LeeBoyoun Park
Apr 9, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bruce B Riley
Sep 3, 2021·Biochimica Et Biophysica Acta. General Subjects·Pablo ArmasNora B Calcaterra

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