CNIO cancer conference: targeted search for anticancer drugs

Expert Opinion on Investigational Drugs
Peter M Fischer

Abstract

The topics discussed at the conference covered many aspects of cancer research, from the genetic search for new targets, target validation and drug discovery, all the way to preclinical and clinical development of oncology drugs. Here the presentations on new metabolic, angiogenic, cell cycle and other molecular targets, as well as recent developments with experimental drugs with action on some of these targets, are summarised. Particular emphasis is placed on the emerging realisation that changes in the metabolic phenotype lie at the heart of cellular transformation. New insights into the biological links between cancer cell metabolism and the balance between survival and death signalling are likely to lead to the identification of a new category of anticancer targets.

References

Dec 11, 1997·Oncogene·R Hernández-AlcocebaJ C Lacal
Dec 2, 2000·Nature·B B Zhou, S J Elledge
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·G Powis, W R Montfort
Dec 13, 2001·Pancreas·Laszlo G BorosVay Liang W Go
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·T UsubaK Ohkawa
Feb 21, 2002·Trends in Endocrinology and Metabolism : TEM·David R Plas, Craig B Thompson
Jun 28, 2002·Cancer Cell·Laura K ShawverAxel Ullrich
Aug 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Adam Siddiqui-JainLaurence H Hurley
Sep 19, 2002·Trends in Pharmacological Sciences·Marie KnockaertLaurent Meijer
Sep 21, 2002·Cancer Cell·Thijn R BrummelkampReuven Agami
Nov 15, 2002·International Journal of Cancer. Journal International Du Cancer·Steven J McClueDavid P Lane
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·Campbell McInnesPeter M Fischer
Dec 2, 1960·Hoppe-Seyler's Zeitschrift für physiologische Chemie·O WARBURGS LORENZ

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.