PMID: 40256May 1, 1979

CNS benzodiazepine receptors: physiological studies and putative endogenous ligands

Pharmacology, Biochemistry, and Behavior
P SkolnickS M Paul

Abstract

The recent demonstration of benzodiazepine receptors in the mammalian CNS has provided new information on the mechanism of action of this important class of drugs. In addition, the presence of these receptors has prompted studies on their physiological significance, including attempts at isolating an endogenous ligand. The isolation of a number of substances from bovine brain that competitively inhibit (3H)-diazepam binding to synaptosomal membrane suggests the presence of an endogenous ligand. Two of these substances have been identified as the purines inosine and hypoxanthine. Pharmacological studies of these purines suggest that they may have diazepam-like effect in vivo. The possibility that the brain may contain its own benzodiazepine-like compound is currently being studied.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C Braestrup, R F Squires
Oct 20, 1977·Nature·C BraestrupR F Squires
Nov 9, 1978·Life Sciences·M J WilliamsonP Skolnick
Dec 1, 1978·Pharmacology, Biochemistry, and Behavior·A S LippaB Beer
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T Asano, S Spector
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P SkolnickS M Paul
Jun 1, 1978·European Journal of Pharmacology·M KarobathG Schönbeck
Apr 21, 1977·Nature·R F Squires, C Brastrup

Citations

Feb 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·D R GehlertJ K Wamsley
Jun 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·T A Voronina
May 21, 1981·Life Sciences·A S LippaL R Meyerson
Oct 1, 1979·Pharmacology, Biochemistry, and Behavior·C A KlepnerB Beer
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·L G DavisD Reker
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·S Pellow, S E File
Jan 1, 1983·Neurochemistry International·M Hamon, P Soubrié
Jan 1, 1981·Neurobiology of Aging·N W PedigoH I Yamamura
Sep 19, 1983·Neuroscience Letters·P F Morgan, T W Stone
Apr 1, 1984·Journal of Psychoactive Drugs·H Shaffer, M E Burglass
Jan 1, 1983·British Journal of Clinical Pharmacology·P Danneberg, K H Weber
Aug 10, 2018·Personality Neuroscience·Neil McNaughton, Luke D Smillie

Related Concepts

Metazoa
Anticonvulsants
Benzodiazepines
Brain
Ligands
Receptors, Drug
Synaptosomes
Anti-Anxiety Effect

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