CNS gene encoding astrotactin, which supports neuronal migration along glial fibers

Science
C ZhengM E Hatten

Abstract

Vertebrate central nervous system (CNS) histogenesis depends on glia-guided migration of postmitotic neurons to form neuronal laminae. Previous studies have established that the neuronal protein astrotactin functions in murine cerebellar granule cell migration in vitro. The gene encoding astrotactin predicts a protein with three epidermal growth factor repeats and two fibronectin type III repeats. Astrotactin messenger RNA is expressed in postmitotic neuronal precursors in the cerebellum, hippocampus, cerebrum, and olfactory bulb, where migration establishes laminar structures. Fab fragments of antibodies to a recombinant astrotactin peptide blocked migration of cerebellar granule neurons in vitro along astroglial fibers. Transfection of astrotactin complementary DNA into 3T3 cells indicated that astrotactin acts as a ligand for neuron-glia binding during neuronal migration.

References

May 3, 1987·Nature·R M CookeB Sheard
Dec 1, 1986·European Journal of Biochemistry·K SkorstengaardS Magnusson
May 1, 1972·The Journal of Comparative Neurology·P Rakic
Aug 1, 1994·Current Opinion in Genetics & Development·I Greenwald
Feb 1, 1993·Current Opinion in Neurobiology·M E Hatten

❮ Previous
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Citations

Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·C A Walsh
Aug 10, 2000·Journal of Neuroscience Research·G Chanas-SacreP Leprince
Mar 14, 2002·Annals of Neurology·David H GutmannMark A Watson
Aug 10, 2006·Immunogenetics·Masaru Nonaka, Ayuko Kimura
Aug 29, 2013·Progress in Neurobiology·Annalisa Buffo, Ferdinando Rossi
Oct 22, 2003·Molecular Genetics and Metabolism·Victor Chizhikov, Kathleen J Millen
Nov 26, 2003·Experimental Neurology·Andreas F MackConcepción Lillo
Jun 26, 1998·Brain Research. Brain Research Reviews·H SupèrH B Uylings
Feb 17, 2000·Trends in Neurosciences·J G Parnavelas
Sep 15, 1998·Trends in Neurosciences·D Goldowitz, K Hamre
Sep 23, 2003·Brain Research. Molecular Brain Research·Mitch PriceJonathan R Day
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Magdi M Sobeih, Gabriel Corfas
Oct 9, 1999·Epilepsy Research·A J Copp, B N Harding
Feb 1, 1997·Current Opinion in Neurobiology·M E HattenN Heintz
May 6, 1998·Current Opinion in Neurobiology·A L PearlmanJ E Brunstrom
Jun 14, 2002·Progress in Retinal and Eye Research·Benjamin E Reese, Lucia Galli-Resta
Aug 17, 2000·Clinical Genetics·B F Uher, J A Golden
May 1, 2009·Nature·Joseph T GlessnerHakon Hakonarson
Sep 15, 2001·The European Journal of Neuroscience·J NacherB S McEwen
Feb 17, 1999·The Journal of Experimental Medicine·S T QureshiD Malo
Nov 1, 1996·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R I Kuzniecky, A J Barkovich
Dec 5, 2002·Genes & Development·Yi RaoJane Y Wu
May 10, 2005·Genes & Development·Todd E AnthonyNathaniel Heintz
Jan 1, 2008·CSH Protocols·Parizad M Bilimoria, Azad Bonni
Aug 25, 2007·Science·Carlos J RosadoJames C Whisstock
Aug 13, 2011·Science Translational Medicine·Anath C LionelStephen W Scherer
Aug 14, 2013·Annual Review of Cell and Developmental Biology·Irina EvsyukovaE S Anton
Apr 15, 1999·Annual Review of Neuroscience·M E Hatten
Aug 25, 2001·Annual Review of Neuroscience·M E Ross, C A Walsh
Mar 11, 2003·Annual Review of Neuroscience·Oscar Marín, John L R Rubenstein
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Perrin M WilsonMary E Hatten
Aug 1, 2008·Medicinski pregled·Radmila GudovićBiljana Krstonosić
Jul 3, 2013·Psychological Medicine·N AntypaA Serretti
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·N W SeedsS P Haffke
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu LiangMark A Israel
Sep 18, 2012·Cellular and Molecular Life Sciences : CMLS·Robert J C GilbertGregor Anderluh

❮ Previous
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