CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats

Neuroreport
Cesar V BorlonganDwaine F Emerich

Abstract

The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependent protection of embryonic cortical neurons against serum deprivation-induced cell death. In vivo studies demonstrated that a one-hour middle cerebral artery occlusion in adult Wistar rats produced profound motor and neurological impairments 1-3 days after stroke. In contrast, stroke animals transplanted with encapsulated choroid plexus cells displayed a significant reduction in both motor and neurological abnormalities. Histological analysis 3 days post-transplantation revealed that choroid plexus transplants significantly decreased the volume of striatal infarction. This is the first report demonstrating the therapeutic potential of transplanted choroid plexus for stroke.

References

Oct 1, 1985·Journal of Neurosurgery·S L AleshireF F Parl
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y H ChiangY Wang
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C V BorlonganH Nishino
Jan 6, 2001·Progress in Brain Research·J L Tseng, P Aebischer
Jul 18, 2002·Circulation·Christoph A Nienaber, Hans-H Sievers
Mar 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Douglas KondziolkaCarolyn Cidis Meltzer
Dec 20, 2003·Current Neurology and Neuroscience Reports·L J Kappelle, H B Van Der Worp
Dec 25, 2003·Cerebrovascular Diseases·Nils Gunnar Wahlgren, Niaz Ahmed

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Citations

Mar 15, 2012·Cellular and Molecular Life Sciences : CMLS·Mauro W Zappaterra, Maria K Lehtinen
Jul 20, 2005·Pharmaceutical Research·Conrad E JohansonAndrew Baird
Nov 19, 2008·Journal of Molecular Neuroscience : MN·C Henrique AlvesCecília R A Santos
Nov 13, 2004·Neuroreport·Cesario V BorlonganDwaine F Emerich
May 11, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jianming XiangRichard F Keep
Jan 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kuti BaruchMichal Schwartz
Oct 17, 2013·Stroke; a Journal of Cerebral Circulation·Hiroto IshikawaCesar V Borlongan
Jun 17, 2014·International Journal of Molecular Sciences·Francisca S Y WongAmy C Y Lo
Jul 23, 2004·Expert Opinion on Biological Therapy·Dwaine F EmerichCesario V Borlongan
Jan 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·M P ZaninR K Shepherd
Nov 16, 2010·Neurochemistry International·Yannick BéjotChristine Marie
Oct 18, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leslie L MuldoonEdward A Neuwelt
Apr 1, 2008·Transplantation Proceedings·O GarkavenkoB R Elliott
Jun 28, 2015·Brain, Behavior, and Immunity·Delphine DemeestereRoosmarijn E Vandenbroucke
Feb 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Dwaine F EmerichChistopher G Thanos
Sep 13, 2008·Anatomia, histologia, embryologia·W De SpiegelaereP Simoens
Nov 8, 2006·Journal of Biomedical Materials Research. Part a·C G ThanosD F Emerich
Jun 14, 2006·Xenotransplantation·Stephen J M SkinnerRobert B Elliott
Jun 17, 2006·Neurobiology of Disease·Dwaine F EmerichJeffrey H Kordower
Feb 25, 2014·Neuroscience Letters·Sheng-Li HuangWei Shi
May 24, 2016·Neural Regeneration Research·Sriram BalusuRoosmarijn E Vandenbroucke
Feb 4, 2006·Cell Transplantation·Dwaine F EmerichChristopher G Thanos
Jul 3, 2018·Expert Review of Neurotherapeutics·Elliot G NealCesario V Borlongan
May 18, 2020·Journal of Neuropathology and Experimental Neurology·Conrad E JohansonEsteban M Rodríguez
Mar 30, 2017·Fluids and Barriers of the CNS·Jianming XiangRichard F Keep
Mar 6, 2015·Expert Review of Neurotherapeutics·Stephanny ReyesCesar V Borlongan
May 8, 2020·Fluids and Barriers of the CNS·Peter SolárMarek Joukal
May 1, 2021·Neuroscience and Biobehavioral Reviews·Inge C M VerheggenWalter H Backes

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