PMID: 9180914Aug 1, 1997Paper

CNS late effects after ALL therapy in childhood. Part II: Conventional EEG recordings in asymptomatic long-term survivors of childhood ALL--an evaluation of the interferences between neurophysiology, neurology, psychology, and CNS morphology. German Late Effects Working Group

Medical and Pediatric Oncology
M A UeberallR Korinthenberg

Abstract

Monitoring of therapy-related late effects after acute lymphoblastic leukemia (ALL) therapy in childhood has become an increasingly important area in posttherapeutic patient surveillance. The usefulness of conventional electro-encephalographic (EEG) investigations as part of these attempts is controversially discussed. However, EEG recordings have become a popular approach for judgement on the functional integrity of the central nervous system in this subject group. The present report focuses on this problem and discusses the question whether and to what extent conventional EEG recordings were correlated with further measures of central nervous system (CNS) integrity and therapeutic differences. EEGs were recorded in 110 subjects, asymptomatic long-term survivors of ALL in childhood, during a large retrospective multicenter study evaluating CNS late sequelae following antileukemic therapy in Germany and Austria. EEG findings were correlated with demographic data, illness- and treatment-related parameters, as well as with data on the morphological, neurological and psychological status of the participating subjects. At the time of follow-up the EEG was abnormal in 47 cases (42.7%). The most frequent EEG abnormalities observed we...Continue Reading

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Citations

Feb 5, 2011·Seizure : the Journal of the British Epilepsy Association·Hadassa Goldberg-SternAvinoam Shuper
Oct 4, 2013·Pediatric Hematology and Oncology·Ayşe İpek KalafatçılarGülersu İrken
Jan 29, 2002·Medical and Pediatric Oncology·M JankovicM van Weel-Sipman
Mar 22, 2001·Medical and Pediatric Oncology·P M LähteenmäkiL A Heikki

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