CNS metabolism in high-risk drug abuse, German version : Insights gained from1 H- and31 P MRS and PET

Der Radiologe
S V Bodea

Abstract

High-risk drug consumption is a considerable problem for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. Whilst most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging. We reviewed the literature reporting neuroimaging studies of in vivo metabolic data for methamphetamine, cocaine and heroin consumption published up to March 2017. The search was conducted using PubMed with the following key words: methamphetamine, cocaine, heroin, MR spectroscopy, PET. MRI and PET are indispensable tools in gauging brain metabolic response to illegal drug abuse. Future breakthroughs in this field will most likely come from the investigation of novel neurotransmitter systems in PET and imaging phosphorus and carbon metabolites in MRI.

References

Jul 1, 1992·Synapse·N D VolkowL Handlesman
May 1, 1991·The American Journal of Psychiatry·N D VolkowA Hoff
May 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J D ChristensenP F Renshaw
May 18, 1999·The American Journal of Psychiatry·L ChangC M Mehringer
Mar 9, 2000·Addiction·J M White, R J Irvine
Apr 6, 2005·Archives of General Psychiatry·Thomas E NordahlMichael H Buonocore
Jan 13, 2010·Das Gesundheitswesen·S MostardtT Pfeiffer-Gerschel
Mar 6, 2010·Annals of the New York Academy of Sciences·Stephanie C Licata, Perry F Renshaw
Oct 16, 2010·Neuropathology and Applied Neurobiology·A Büttner
Jul 27, 2012·The Australian and New Zealand Journal of Psychiatry·Anand GururajanMaarten van den Buuse
Oct 23, 2012·Drug and Alcohol Dependence·Young-Hoon SungPerry F Renshaw
Mar 8, 2013·Behavioural Brain Research·Young-Hoon SungDeborah A Yurgelun-Todd
Jul 31, 2013·Life Sciences·Laura E HalpinBryan K Yamamoto
Apr 11, 2014·Drug and Alcohol Dependence·David MatuskeyYu-Shin Ding
Jan 1, 2012·Brain Sciences·Reem K JanBruce R Russell

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