PMID: 39974Jan 1, 1978

CNS Modulation of adrenal tyrosine hydroxylase in Parkinson's disease and metabolic encephalopathies

Journal of Neural Transmission. Supplementum
P RiedererD Seemann


Tyrosine hydroxylase (TH) activity was assayed radioenzymatically in various regions of post-mortem brains of human individuals without neurologic disorders (controls), with Parkinson's disease, senile dementia, hypertensive encephalopathy, hepatic and diabetic coma, liver cirrhosis without coma, and hepatic coma treated with parenteral administration of L-valine. In addition TH activity of the post-mortem adrenal medulla was assayed in controls, in Parkinson's disease, senile dementia and hypertensive encephalopathy. In Parkinson's disease TH activity was significantly decreased in the nigrostriatal system, and less severe in other brainstem areas, while the raphé-reticular formation and limbic system showed normal values. In addition, there was significant decrease in the TH activity of the adrenal medulla, suggesting that Parkinson's disease is a generalized disorder not limited to distinct CNS areas, and that impairment of the dopaminergic niggro-striatal system may involve the TH activity in the adrenal medulla, thus inducing disorders of the peripheral sympathetic system. Senile brain atrophy showed no definite changes in brain, except the striatum, and adrenomedullary TH, while in one case of hypertensive encephalopathy ...Continue Reading

Related Concepts

Brain Pathology
Senile Paranoid Dementia
Diabetes With Coma (Disorder)
Fulminant Hepatic Failure With Cerebral Edema
Fibrosis, Liver
Parkinson Disease
Tyrosine 3-Monooxygenase

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