CNS neurotrophins are biologically active and expressed by multiple cell types

Journal of Molecular Histology
Catherine P RileyC R Buck


Neutrotrophins are increasingly appreciated as potential modulators of neuronal function in the adult central nervous system (CNS). To describe the neurotrophin environment within the adult CNS, mRNA and protein expression patterns of neurotrophins-3 and -4 and of brain-derived neurotrophin were investigated in adult rat spinal cord and brain. Co-localization studies with CNS cell type-specific markers demonstrates that multiple cell types, including both neurons and glia, express these neurotrophins in the normal adult CNS. Although widely implicated in important CNS functions such as synaptic plasticity, biological activity of endogenous CNS neurotrophins has not been directly demonstrated. With a sensitive neurite outgrowth bioassay we demonstrate that CNS neurotrophins elicit neurite outgrowth and are biologically active. Moreover, antibody-blocking studies suggest that these three neurotrophins may comprise the bulk of adult CNS neurotrophic activity.


Aug 12, 2009·Journal of Neural Transmission·Ruth Arnon, Rina Aharoni
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ramendra N SahaKalipada Pahan
Apr 25, 2012·Neurocritical Care·Sabrina GiacoppoSilvia Marino
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jerome JeanblancDorit Ron
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rina AharoniRuth Arnon
Jun 21, 2014·Pharmacological Reports : PR·Tina Mele, Damijana M Jurič
Oct 20, 2010·Expert Opinion on Biological Therapy·Tanya J Wyatt, Hans S Keirstead
Apr 19, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jason C StanwickMolly S Shoichet
Feb 1, 2011·Neuropharmacology·Damijana M JuričMarija Carman-Krzan
Oct 27, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tina MeleDamijana M Jurič
Oct 31, 2006·Frontiers in Neuroendocrinology·Farida Sohrabji, Danielle K Lewis
Apr 17, 2007·The European Journal of Neuroscience·M Youssoufian, B Walmsley
Feb 6, 2010·Journal of Neurochemistry·Scott E Counts, Elliott J Mufson
Jul 11, 2006·Brain Research·Damijana M JuričMarija Carman-Krzan
Sep 19, 2006·Neuroscience Letters·Ronald DeumensElbert A J Joosten
Nov 30, 2010·Journal of Neuroimmunology·Sakhina Begum-HaqueLloyd H Kasper
Aug 8, 2007·Neurochemistry International·Damijana M JuričMarija Carman-Krzan
Jul 3, 2013·Neurochemistry International·Farida SohrabjiDanielle K Lewis
Apr 27, 2016·Toxicology Letters·Damijana M JuričMiran Brvar
Dec 22, 2016·International Journal of Molecular Sciences·Andrea KwakowskyRichard L Faull
Apr 13, 2017·Development and Psychopathology·Jennifer Blaze, Tania L Roth
Feb 6, 2007·The Journal of Comparative Neurology·Darren M HessRita J Balice-Gordon
Feb 12, 2014·Alternatives to Laboratory Animals : ATLA·Elizabeth K WoehrlingMichael D Coleman


Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M TaniuchiE M Johnson
Dec 1, 1988·Brain Research. Developmental Brain Research·C R BuckI B Black
Sep 4, 1987·Science·R Levi-Montalcini
Dec 1, 1994·Brain Research. Molecular Brain Research·M Alvarez-DoladoA Muñoz
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·L TessarolloL F Parada
Jan 1, 1996·Seikagaku. The Journal of Japanese Biochemical Society·Y FurukawaK Hayashi
Feb 1, 1996·Current Opinion in Neurobiology·C E Henderson
Jan 1, 1996·Annual Review of Neuroscience·G R Lewin, Y A Barde
Sep 12, 1997·Science·F W Pfrieger, B A Barres
Mar 11, 1999·Current Opinion in Neurobiology·E M Schuman
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Apr 23, 1999·Journal of Neuroscience Research·C F DreyfusI B Black
May 20, 1999·International Review of Cytology·D M WeisenhornB H Wainer
Sep 7, 1999·Journal of Neuroscience Methods·S ZhangR A Rush
Sep 30, 1999·Journal of Neurobiology·I B Black
Dec 22, 1999·The Journal of Comparative Neurology·C R BuckT C Cope
Apr 13, 2000·The European Journal of Neuroscience·E SermasiL Domenici
Nov 4, 2000·Neurochemical Research·L F EngY L Lee
Feb 7, 2001·Science·E M UllianB A Barres
Oct 1, 1954·Proceedings of the National Academy of Sciences of the United States of America·S CohenV Hamburger
May 1, 2001·Current Protocols in Toxicology

Related Concepts

Establishment and Maintenance of Localization
Rat Spinal Cord
Neurite Outgrowth
Neurotrophic factor
BDNF gene
Brain-Derived Neurotrophic Factor
Neurotrophin Binding

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