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CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis

Human Molecular Genetics

Mar 15, 2015

Lu ChenFeng Wei Zhang

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Abstract

Copy number variation (CNV) in the human genome is of vital importance to human health and evolution of our species. However, much of the molecular basis of CNV mutagenesis remains to be elucidated. Considering the DNA replication model of 'fork stalling and template switching' for CNV ...read more

Mentioned in this Paper

Calochortus elegans
Ceramium elegans
Clathrulina elegans
Ceropegia elegans
Chrysis elegans
Cheiromoniliophora elegans
Chaerophyllum elegans
Compsocus elegans
Homologous Gene
Chamaedorea elegans
1
28
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CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis

Human Molecular Genetics

Mar 15, 2015

Lu ChenFeng Wei Zhang

PMID: 25398944

DOI: 10.1093/hmg/ddu572

Abstract

Copy number variation (CNV) in the human genome is of vital importance to human health and evolution of our species. However, much of the molecular basis of CNV mutagenesis remains to be elucidated. Considering the DNA replication model of 'fork stalling and template switching' for CNV ...read more

Mentioned in this Paper

Calochortus elegans
Ceramium elegans
Clathrulina elegans
Ceropegia elegans
Chrysis elegans
1
28

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