PMID: 7547678Apr 1, 1995Paper

Co-activation of naive CD4+ T cells and bone marrow-derived mast cells results in the development of Th2 cells

International Immunology
C HuelsE Schmitt

Abstract

Activation of naive dense CD4+ T cells by plate-bound anti-CD3 antibodies favors the development of Th1 cells which, upon re-stimulation, produce significant amounts of IFN-gamma but no IL-4. However, co-activation of such naive T cells in the presence of IgE [anti-dinitrophenyl (DNP)]-loaded bone marrow-derived mast cells (BMMC) on plates coated with anti-CD3 antibodies and DNP-BSA led to the development of IL-4-producing Th2 cells. The same result could be observed if irradiated (800 rad) BMMC were applied as co-stimulators. Moreover, BMMC could be replaced by the supernatant of IgE-activated BMMC suggesting that a soluble mediator, presumably IL-4, was responsible for this effect. This assumption was substantiated using neutralizing anti-IL-4 antibodies which abolished the BMMC-mediated Th2 development in all cases. Addition of IL-12, a cytokine that was shown to antagonize the Th2-promoting effect of IL-4 in vivo, could not inhibit the development of IL-4-producing T cells, but gave rise to a T cell population which produced relatively high amounts of IL-4 and IFN-gamma. Since BMMC represent the in vitro equivalent of mucosal mast cells these data suggest that IgE-activated mucosal mast cells can bias an emerging T cell dep...Continue Reading

Citations

Jun 1, 1996·Current Opinion in Immunology·P C Beverley
Aug 19, 1999·Critical Reviews in Oncology/hematology·P Bradding, S T Holgate
Mar 16, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Shigetoshi HoriguchiKouichi Kobayashi
Oct 7, 2009·Blood·Nicolas GaudenzioEric Espinosa
Feb 10, 2011·Clinical and Molecular Allergy : CMA·Eun-Hwa SohnSun-Young Kim
Oct 23, 2012·Indian Journal of Pharmacology·Sang-Joon ParkEun-Joo Kim
Jan 1, 1996·International Journal of Clinical & Laboratory Research·S Romagnani
Nov 23, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J M BrownD D Metcalfe
Nov 22, 2005·Cytokine & Growth Factor Reviews·Christoph BeckerMarkus F Neurath
Mar 16, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J WilsonP Bradding
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P Bradding, E C Conley
Jun 1, 1996·European Journal of Immunology·I AokiD M Klinman
May 1, 1996·European Journal of Immunology·F H FalconeH Haas
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rommel Chacón-SalinasStephen E Ullrich
Feb 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Krisztina V VukmanSandra M O'Neill
Jun 25, 2013·Journal of Leukocyte Biology·Krisztina V VukmanSandra M O'Neill
Nov 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Peter Bradding, Greer Arthur
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M StassenE Schmitt
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Peter Bradding
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott N ByrneStephen E Ullrich
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun-Keung Yu, Chih-Long Chen
Dec 2, 2020·Cells·Konstantinos Katsoulis-DimitriouAnne Dudeck

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