Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level in rats

Journal of Biomedical Science
Dong-Yih Kuo

Abstract

This study investigated whether co-administration of dopamine D1 and D2 agonists might additively inhibit the feeding effect and whether this effect was mediated by the action on hypothalamic neuropeptide Y (NPY). The D1 agonist SKF 38393 (SKF) and D2 agonists apomorphine (APO) or quinpirole (QNP) were administered, alone or in combination, to examine this possibility. In single administration, decreases of daily food intake were observed only in rats treated twice a day with a higher dose of SKF, APO or QNP. However, combined administration of D1 and D2 agonists, with each agent at a dose that alone did not induce anorexia in one daily treatment, exerted a significant effect. These results reveal that co-activation of D1 and D2 receptors can additively reduce daily food intake and body weight. The same treatment also decreased the level of hypothalamic NPY 24 h post-treatment. These results suggest an additive effect during combined activation of D1 and D2 receptor subtypes to decrease food intake and body weight that are mediated by the action of hypothalamic NPY. Similar to the effects seen in healthy rats, combined D1/D2 administration was also effective in the reduction of food intake in diabetic rats, revealing the effici...Continue Reading

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Aug 15, 1978·European Journal of Pharmacology·P E SetlerH L Saunders
Feb 11, 1992·Trends in Pharmacological Sciences·D R Sibley, F J Monsma
Jan 1, 1991·General Pharmacology·M R ZarrindastT Hosseini-Nia
Aug 1, 1987·Endocrine Reviews·J E Morley
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B G Stanley, S F Leibowitz
Jan 1, 1984·Regulatory Peptides·J M AllenS R Bloom
Nov 1, 1984·Peptides·A S Levine, J E Morley
Aug 1, 1993·Pharmacology & Toxicology·R Samanin, S Garattini
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Feb 11, 1998·Physiological Reviews·C MissaleM G Caron
Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·S M AjaD W Gietzen

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Citations

Mar 17, 2004·Neurotoxicology and Teratology·Lena MorónEnrique Echevarría
Mar 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne Marie D AxelHenrik H Hansen
Oct 15, 2013·Veterinary Research Communications·Morteza ZendehdelShahin Hassanpour
Aug 19, 2015·Cell Metabolism·Raphaël G P DenisSerge Luquet
Dec 21, 2011·Neuropharmacology·Dong-Yih KuoShu-Chen Chu
May 3, 2015·Pharmacology, Biochemistry, and Behavior·Paula Honório de Melo MartimianoManuela Figueiroa Lyra de Freitas
Mar 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Liang YeYouxin Li
Oct 3, 2013·Pharmacology, Biochemistry, and Behavior·Darakhshan Jabeen HaleemMuhammad Abdul Haleem
Jun 14, 2013·PloS One·Roxanne DutiaSharon L Wardlaw
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline DavisJames L Kennedy
Mar 7, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicholas M WallingfordMichael A Cowley
Jul 23, 2003·Animal Genetics·A HaegemanL J Peelman
Dec 23, 2015·Assay and Drug Development Technologies·Joel A Morales-RosadoEric W Klee
May 10, 2016·The International Journal of Eating Disorders·Emilee E BurgessMary M Boggiano
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Petra KokHanno Pijl
Feb 2, 2018·Physiological Reports·Shahana FedeleAbdelhak Mansouri
Sep 27, 2005·Physiological Reviews·Sarah StanleyStephen Bloom

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