Co-administration of etomoxir and RU-486 mitigates insulin resistance in hepatic and muscular tissues of STZ-induced diabetic rats

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
M S Bitar

Abstract

Insulin resistance is a condition of central importance in a cluster of clinical disorders including diabetes mellitus, hypertension, dyslipidemia, central obesity and coronary heart disease. Despite its association with numerous health problems, the mechanism responsible for the development of this phenomenon remains to be established. A novel theory has proposed that insulin resistance in diabetes stems, at least in part, from enhanced free fatty acid (FFA) oxidation and/or excessive production of glucocorticoids (GCs). Several key predictions of this premise were subjected to experimental testing using streptozotocin (STZ)-treated rats as a model for insulin-dependent diabetes mellitus and euglycemic-hyperinsulinemic clamp technique for the in vivo measurement of insulin actions. Euglycemic clamp studies with an insulin infusion index of 5 mU/kg/min were used to measure endogenous glucose production (EGP), glucose infusion rate (GIR), glucose disposal rate (GDR) and skeletal muscle glucose utilization index (GUI). Post-absorptive basal EGP and plasma levels of glucose and free fatty acids (FFA) were elevated in the STZ diabetic rats compared to their corresponding control values. In contrast, hypoinsulinemia was evident in t...Continue Reading

Citations

May 13, 2008·Cardiovascular Drugs and Therapy·Tong-Guo WuLe-Xin Wang
Dec 7, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Jeremy W Tomlinson, Paul M Stewart
Oct 17, 2015·Blood·Ismael Samudio, Marina Konopleva
Dec 13, 2007·The Medical Journal of Australia·Mary Lander
Jul 27, 2021·Journal of the American Heart Association·Swayam Prakash SrivastavaJulie Goodwin

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