Co-administration of genistein with doxorubicin-loaded polypeptide nanoparticles weakens the metastasis of malignant prostate cancer by amplifying oxidative damage

Biomaterials Science
Guanyi WangXueqi Fu

Abstract

Prostate cancer is a typical malignant disease with a high incidence and a poor prognosis. Doxorubicin hydrochloride (DOX·HCl) is one of the most effective agents in the treatment of prostate cancer, but severe side effects and metastasis after its treatment impose restrictions on its application. Herein, a combination of genistein (GEN) and doxorubicin-loaded polypeptide nanoparticles (DOX-NPs) is constructed for the treatment of prostate cancer. The DOX-NPs can reduce the side effects caused by free DOX·HCl and produce a relatively low level of intracellular reactive oxygen species (ROS)-induced oxidative damage, while GEN, an inhibitor of the oxidative DNA repair enzyme apurinic/apyrimidinic endonuclease1 (APE1), can further amplify the ROS-induced oxidative damage by downregulating the intracellular expression of APE1 and reducing oxidative DNA repair in the prostate cancer cells. Because high levels of ROS-induced oxidative damage can prevent the distant metastasis of tumor cells, the distant metastasis of malignant prostate cancer cells is significantly inhibited by the combination of genistein and DOX-NPs with amplified oxidative damage.

References

Apr 19, 2005·Cancer Research·Sharon A VantyghemAnn F Chambers
Sep 1, 2005·Prostate Cancer and Prostatic Diseases·G A SonnM S Litwin
Jun 15, 2007·Molecular Aspects of Medicine·Melissa L Fishel, Mark R Kelley
Dec 7, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dae Goon YooByeong Hwa Jeon
Mar 15, 2008·Cancer Research·Minalini LakshmanRaymond C Bergan
Sep 24, 2008·Molecular and Cellular Biology·Ranajoy ChattopadhyayKishor K Bhakat
Dec 11, 2008·British Journal of Cancer·J SheridanJ O'Sullivan
Mar 28, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dong WangYun-Song Zhang
Sep 24, 2013·Oxidative Medicine and Cellular Longevity·Chih-Chien SungChia-Chao Wu
Jun 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hailiang WuKazunori Kataoka
Feb 12, 2015·Cancer Cell·Paul T Schumacker
Jun 18, 2015·International Journal of Oncology·Shaojie JiangGang-Ming Zou
Oct 16, 2015·Nature·Elena PiskounovaSean J Morrison
Nov 26, 2015·Food Chemistry·Maria RussoSeyed Mohammad Nabavi
Dec 5, 2015·Cell Metabolism·Maria Peiris-PagèsMichael P Lisanti
May 25, 2016·Theranostics·Wantong SongXuesi Chen
May 28, 2016·Chonnam Medical Journal·Sunga ChoiByeong Hwa Jeon
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Taylor RohMyeong Jin Nam
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 21, 2017·Journal of Cellular Biochemistry·Martha L Pinzón-DazaRuth Garzón
Jun 11, 2018·ACS Biomaterials Science & Engineering·Na ShenXuesi Chen

❮ Previous
Next ❯

Citations

Dec 3, 2020·Biology·Margalida Torrens-Mas, Pilar Roca
Dec 18, 2020·Frontiers in Oncology·Francisco Alejandro Lagunas-Rangel, Rosa María Bermúdez-Cruz
Oct 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María D Navarro-HortalJosé L Quiles
Jul 23, 2021·Cancer Cell International·Zeeshan JavedJavad Sharifi-Rad

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
flow cytometry

Software Mentioned

SPSS
Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.