Co-Administration of the Traditional Medicines Hachimi-Jio-Gan and Hochu-Ekki-To Can Reverse Busulfan-Induced Aspermatogenesis

International Journal of Molecular Sciences
Ning QuMasahiro Itoh

Abstract

Busulfan is used as a chemotherapeutic drug to treat childhood and adult chronic myelogenous leukemia, and as an immunosuppressive agent before bone marrow transplantation. A key side effect of busulfan is the alteration of male reproductive function. Infertility caused by anti-cancer treatments has become a significant concern, but there are currently limited treatments for this condition. Recently, we demonstrated that Gosha-jinki-gan, a traditional Japanese medicine, completely reversed the spermatogenesis defects caused by cancer treatment in mice. Hochu-ekki-to and Hachimi-jio-gan are commonly used to treat male infertility, and Hachimi-jio-gan shares herbal ingredients with Gosha-jinki-gan. Therefore, in the present study, we administered Hachimi-jio-gan and Hochu-ekki-to alone or in combination to mice with severe aspermatogenesis caused by busulfan treatment. We performed testis weight measurements, quantitative histological assessments of the testes and the epididymis, and evaluated sperm counts and morphology. We also assessed the expression of immune mediators and macrophage markers. Treatment with a combination of both the medicines significantly reduced busulfan-induced testicular toxicity when compared to the lone...Continue Reading

References

Sep 1, 1994·The Annals of Pharmacotherapy·I BuggiaM Zecca
Jan 1, 1994·The American Journal of Chinese Medicine·T NakayamaS Tashiro
Jul 16, 1999·BMJ : British Medical Journal·J L TangE Ernst
Mar 23, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Hiroshi OkaYutaka Shimada
Apr 19, 2011·Animal Reproduction Science·T R KannakiP C Verma
Sep 21, 2012·Methods in Molecular Biology·Marvin L Meistrich, Rex A Hess
Nov 20, 2012·Expert Opinion on Drug Metabolism & Toxicology·Ariane Galaup, Angelo Paci
Sep 18, 2015·Frontiers in Pharmacology·Kojiro Yamaguchi
Sep 16, 2017·Molecular Human Reproduction·Deepa Bhartiya, Sandhya Anand
Sep 5, 2018·International Journal of Molecular Sciences·Ning QuMasahiro Itoh
Mar 1, 2019·International Journal of Molecular Sciences·Ning QuKou Sakabe
Mar 22, 2019·Oncology Reports·Sofía Del-Pozo-LéridaPepita Giménez-Bonafé
Dec 13, 2019·BMC Complementary and Alternative Medicine·Kumpei TakahashiMasahiro Itoh

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
PCR

Software Mentioned

Thermal Cycler Dice Real - time System

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.