Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training

Neuroreport
G R IbarraJ M Azcurra

Abstract

CIRCLING training (CT) decreases muscarinic acetyl-choline receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and sacrificed 2 months later showed an enduring drop in Bmax of 40% in DA D2 and 34% in mAchR. Plotting the percentage of binding drop of both receptors for each animal showed that the reduction of one system correlates with the other (r2 = 0.71, p < 0.01; n = 8). Neither mAchR nor DA D2 were affected when training started at 20 or 60 days. We conclude that the presence of a period where CT exerts long term alterations during development involves both cholinergic and dopaminergic systems.

Citations

Feb 23, 1999·Journal of Neurobiology·M J WolanskyJ M Azcurra
Oct 16, 2003·Brain Research. Molecular Brain Research·Julio M AzcurraGustavo Ch Paratcha
May 18, 2012·Science Translational Medicine·Wuh-Liang HwuRuey-Meei Wu
Aug 23, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mariano Soiza-Reilly, Julio M Azcurra
Jun 19, 2004·Neurotoxicology and Teratology·Marcelo Javier WolanskyJulio Marcos Azcurra
Mar 14, 2019·Annals of Neurology·Chih-Hsien TsengWuh-Liang Hwu
Dec 6, 2018·Biochemical Society Transactions·Deanna L BensonGeorge W Huntley

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