Co-amorphous systems for the delivery of poorly water-soluble drugs: recent advances and an update.

Expert Opinion on Drug Delivery
Jiawei HanShuai Qian

Abstract

Most new drug candidates under development are poorly water-soluble, which are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by the improvement of solubility/dissolution has become a major concern to develop efficacious drugs with reasonable dosing regimens for patients. Over the past decade, increasing reports have been published on the investigation of co-amorphous drug delivery systems, with positive and excited outcomes in improving in vitro and in vivo performances of poorly water-soluble drugs. This review summarizes recent findings of co-amorphous systems and provides their updates as a comprehensive overview in terms of classification, co-formers selection, preparation methods, physicochemical characteristics and in vivo performances. Co-amorphous system, a homogeneous single-phase system containing two compatible drugs or a drug with a pharmaceutically acceptable small-molecule co-former, has been employed as a promising formulation technology to improve in vitro and in vivo performances of poorly water-soluble drugs such as solubility/dissolution, stability, mechanical properties and bioavailability. Furthermore, a deeper understanding of co-amorphous systems, including its d...Continue Reading

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Citations

Mar 23, 2021·Therapeutic Delivery·Ridhima SinghAbhay T Sangamwar
Jun 19, 2021·International Journal of Pharmaceutics·Jingwen LiuHolger Grohganz
Jun 14, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ya-Wei LiNian-Qiu Shi
Aug 8, 2021·International Journal of Pharmaceutics·Wen LiQiang Fu

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