Co-causation of reduced newborn size by maternal undernutrition, infections, and inflammation

Maternal & Child Nutrition
P AshornKathryn G Dewey

Abstract

More than 20 million babies are born with low birthweight annually. Small newborns have an increased risk for mortality, growth failure, and other adverse outcomes. Numerous antenatal risk factors for small newborn size have been identified, but individual interventions addressing them have not markedly improved the health outcomes of interest. We tested a hypothesis that in low-income settings, newborn size is influenced jointly by multiple maternal exposures and characterized pathways associating these exposures with newborn size. This was a prospective cohort study of pregnant women and their offspring nested in an intervention trial in rural Malawi. We collected information on maternal and placental characteristics and used regression analyses, structural equation modelling, and random forest models to build pathway maps for direct and indirect associations between these characteristics and newborn weight-for-age Z-score and length-for-age Z-score. We used multiple imputation to infer values for any missing data. Among 1,179 pregnant women and their babies, newborn weight-for-age Z-score was directly predicted by maternal primiparity, body mass index, and plasma alpha-1-acid glycoprotein concentration before 20 weeks of ges...Continue Reading

Associated Clinical Trials

References

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Citations

Feb 2, 2019·Frontiers in Pediatrics·Anja SasoKirsty Le Doare
Feb 23, 2019·Open Forum Infectious Diseases·Kira L NewmanHelen Y Chu
May 16, 2019·Annual Review of Nutrition·Michael K GeorgieffSarah E Cusick

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Clinical Trials Mentioned

NCT01239693

Software Mentioned

R
DYAD
Stata

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