Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young children

Vaccine
Qingfu Xu, Michael E Pichichero

Abstract

Streptococcus pneumoniae (Spn), Haemophilus influenzae (Hi) and Moraxella catarrhalis (Mcat) are common bacterial pathogens of respiratory infections and common commensal microbes in the human nasopharynx (NP). The effect of interactions among theses bacteria during co-colonization of the NP on the host immune response has not been evaluated. The objective of this study was to assess the impact of co-colonization by Hi or Mcat on the systemic antibody response to vaccine protein candidate antigens of Spn and similarly the impact of co-colonization by Spn and Mcat on antibody responses to Hi vaccine protein candidate antigens. Serum samples were collected from healthy children at 6, 9, 15, 18, and 24 months of age when they were colonized with Spn, Hi, Mcat or their combinations. Quantitative ELISA was used to determine serum IgA and IgG against three Spn antigens and three Hi antigens, and as well as whole cells of non-typeable (NT) Spn and Hi. NP colonization by Spn increased serum IgA and IgG titers against Spn antigens PhtD, PcpA and PlyD and whole cells of NTSpn, and co-colonization of Hi or Mcat with Spn resulted in further increases of serum pneumococcal-specific antibody levels. NP colonization by Hi increased serum IgA ...Continue Reading

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Oct 25, 2012·Emerging Infectious Diseases·Qingfu XuMichael E Pichichero

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Citations

Oct 23, 2015·International Journal of Pediatric Otorhinolaryngology·Matthew C MorrisMichael E Pichichero
Nov 6, 2015·Human Vaccines & Immunotherapeutics·Michael E PichicheroQingfu Xu
Feb 11, 2015·Human Vaccines & Immunotherapeutics·M Nadeem Khan, Michael E Pichichero
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wouter A A de Steenhuijsen PitersDebby Bogaert
Feb 2, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Q XuM E Pichichero

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