Co-culture of arbuscular mycorrhiza-like fungi (Piriformospora indica and Sebacina vermifera) with plant cells of Linum album for enhanced production of podophyllotoxins: a first report

Biotechnology Letters
Ashish BaldiV S Bisaria

Abstract

Cell suspension cultures of Linum album were developed from internode portions of in vitro germinated plant in Gamborg's B5 medium supplemented with 0.4 mg naphthalene acetic acid/l. The highest biomass was 8.5 g/l with podophyllotoxin and 6-methoxypodophyllotoxin at 29 and 1.9 mg/l, respectively after 12 d cultivation. Co-cultures of L. album cells with axenically cultivable arbuscular mycorrhiza-like fungi, Piriformospora indica and Sebacina vermifera, were established for the first time. These enhanced podophyllotoxin and 6-methoxypodophyllotoxin production by about four- and eight-fold, respectively, along with a 20% increase in biomass compared to the control cultures.

References

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Citations

Dec 4, 2009·Applied Microbiology and Biotechnology·Pamela J WeathersJianfeng Xu
Feb 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karla Ramirez-EstradaJavier Palazon
Dec 31, 2015·World Journal of Microbiology & Biotechnology·Prasun Ray, Kelly D Craven
Jan 10, 2012·Current Opinion in Biotechnology·Eng-Kiat Lim, Dianna Bowles
Mar 13, 2010·Biotechnology and Applied Biochemistry·Emmanuelle LautiéMaria Luisa Villarreal
Oct 22, 2008·Biotechnology Journal·Ashish BaldiVirendra S Bisaria
Jul 4, 2020·Critical Reviews in Food Science and Nutrition·Himanshu ChhillarMohd Ashraf Ashfaq
May 1, 2021·Biomolecules·Zinnia ShahBianca Popovici

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