Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance

Biomaterials
Huijun ZhuSi-Shen Feng

Abstract

We report a strategy to make use of poly(lactic-co-glycolic acid) nanoparticle (PLGA NPs) for co-delivery of docetaxel (DTX) as a model anticancer drug together with vitamin E TPGS. The latter plays a dual role as a pore-forming agent in the nanoparticles that may result in smaller particle size, higher drug encapsulation efficiency and faster drug release, and also as a bioactive agent that could inhibit P-glycoprotein to overcome multi-drug resistance of the cancer cells, The DTX-loaded PLGA NPs of 0, 10, 20 and 40% TPGS were prepared by the nanoprecipitation method and then characterized for their size and size distribution, surface morphology, physical status and encapsulation efficiency of the drug in the NPs. All four NPs were found of size ranged 100-120 nm and EE ranged 85-95% at drug loading level around 10%. The in vitro evaluation showed that the 48 h IC50 values of the free DTX and the DTX-loaded PLGA NPs of 0, 10, 20% TPGS were 2.619 and 0.474, 0.040, 0.009 μg/mL respectively, which means that the PLGA NPs formulation could be 5.57 fold effective than the free DTX and that the DTX-loaded PLGA NPs of 10 or 20% TPGS further be 11.85 and 52.7 fold effective than the DTX-loaded PLGA NPs of no TPGS (therefore, 66.0 and ...Continue Reading

References

Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S MitraA N Maitra
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Mu, S S Feng
Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Aug 27, 2004·Drugs·Diana E Lake, Clifford A Hudis
Oct 19, 2004·Cancer Letters·Thambi Dorai, Bharat B Aggarwal
Jul 14, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M A Schubert, C C Müller-Goymann
Aug 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shilpa SantPatrice Hildgen
Sep 10, 2005·American Journal of Respiratory and Critical Care Medicine·Svetlana GelperinaLeonid Heifets
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·Sangamesh G KumbarCato T Laurencin
Feb 6, 2007·Molecular Pharmaceutics·Jichao Kang, Steven P Schwendeman
Sep 20, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Harivardhan ReddyPatrick Couvreur
Feb 6, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Xiaowen DaiClemens F Kaminski
May 31, 2008·International Journal of Cancer. Journal International Du Cancer·Constantina ConstantinouAndreas I Constantinou
Oct 8, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Soon Eon BaeDong Keun Han
Apr 7, 2009·Nano Letters·Steven D PerraultWarren C W Chan
May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Fei YanLaiqiang Huang
Oct 22, 2009·Small·Ayush Verma, Francesco Stellacci
Mar 11, 2010·Current Drug Metabolism·Che-Ming Jack Hu, Liangfang Zhang
Feb 7, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J BuskeK G Wagner
Apr 14, 2012·Biomaterials·Zhiping ZhangSi-Shen Feng

❮ Previous
Next ❯

Citations

Sep 16, 2014·Annales pharmaceutiques françaises·R Ouvinha de OliveiraG Barratt
Oct 14, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Duarte de Melo-DiogoIlídio J Correia
Dec 30, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dalia Y SosaRaúl G López
Jul 16, 2014·Drug Development and Industrial Pharmacy·Xu BaoYan Tian
Dec 3, 2014·Biotechnology Advances·Shengpeng WangMeiwan Chen
Jan 1, 2016·ACS Applied Materials & Interfaces·Wing-Fu LaiAndrey L Rogach
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Binquan WuXuemei Sui
Sep 28, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jing LiDavid Oupický
Nov 4, 2015·Acta Biochimica Et Biophysica Sinica·Guojin HuangJianqiang Zhao
Apr 12, 2016·Colloids and Surfaces. B, Biointerfaces·Baoxia LiuDecheng Wu
Aug 22, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Valeria MeliSergio Murgia
Apr 14, 2015·International Journal of Pharmaceutics·Zilan ZhouYuet-Kin Leung
Feb 5, 2015·Nutrition and Cancer·Aysegul Cort, Tomris Ozben
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Xiaolong TangLeilei Sun
Feb 1, 2015·International Journal of Biological Macromolecules·Zhenshun LiBin Li
Mar 21, 2015·Journal of Materials Science. Materials in Medicine·Jinxie ZhangLaiqiang Huang
Jan 20, 2015·Nanomedicine·Sangeetha KrishnamurthyYi Yan Yang
May 11, 2016·Biomaterials·Cristina NúñezCarlos Lodeiro
May 5, 2016·ACS Applied Materials & Interfaces·Zhi DaiLin Zhu
Jul 1, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Hongli ChenQiqing Zhang
Oct 19, 2016·Ultrasound in Medicine & Biology·Boriphat Methachan, Kamolrat Thanapprapasr
Aug 26, 2016·Expert Opinion on Drug Delivery·Omkara Swami MuddinetiSwati Biswas
Mar 27, 2018·Journal of Biomedical Materials Research. Part a·Nafise OlovHamid Mirzadeh
Sep 29, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Maryam AfsharzadehMohammad Ramezani
Apr 3, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Shi-Xin LinDavid J Young
Dec 18, 2018·Pharmaceutical Development and Technology·Lijun ZhenJiangnan Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.