Co-delivery system of chemotherapy drugs and active ingredients from natural plants: a brief overview of preclinical research for cancer treatment

Expert Opinion on Drug Delivery
Pu GuoLing Zhao

Abstract

Introduction: Many active ingredients from natural plants (AINPs) have been revealed to possess remarkable anticancer properties. Combination chemotherapy of chemo-drugs and AINPs has also proven to be more advantageous than individual chemo-drug treatment with respect to enhancing efficiency, alleviating toxicity, and controlling the development of multidrug resistance (MDR). Co-delivery is considered a promising method to effectively achieve and manage combination chemotherapy of chemo-drugs and AINPs, and various distinctive and functional co-delivery systems have been designed for these purposes to date.Areas covered: This review focuses on recent preclinical investigations of co-delivery systems for chemo-drugs and AINPs as new cancer treatment modalities. We particularly emphasize the apparent treatment advantages of these approaches, including augmenting efficiency, reducing toxicity, and controlling MDR.Expert opinion: There has already been notable progress in the application of combination chemotherapy with co-delivery systems loaded with chemo-drugs and AINPs based on results with cellular and animal models. The main challenge is to translate these successes into new anticancer compound preparations and promote their...Continue Reading

References

Jun 29, 2011·Anti-cancer Agents in Medicinal Chemistry·Susmita MondalChitra Mandal
Mar 17, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xiaojing ZhaoXiangliang Yang
Oct 11, 2015·The Journal of Pharmacy and Pharmacology·Xinru LiGuiling Li
Feb 20, 2016·Mini Reviews in Medicinal Chemistry·Pawan TekchandaniShivani Rai Paliwal
Oct 14, 2016·International Journal of Molecular Sciences·Hui LiuHui Huang
Nov 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Markus RäsänenKari Alitalo
Nov 24, 2016·International Journal of Oncology·Zhiwei XuYan Tan
Dec 4, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wenzhuan MaPengfei Tu
Dec 23, 2016·Archives of Toxicology·Q ShiR W Godschalk
Mar 28, 2017·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hsiu WuPhilip J Peters
Mar 31, 2017·Scientific Reports·Bożena Bruhn-OlszewskaJoanna Jakóbkiewicz-Banecka
Apr 18, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meiling YuXiaolin Liu
Apr 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peng-Chen DaiGuo-Xiang Lai
Jun 16, 2017·Journal of Cellular Physiology·Hamed MirzaeiMahmoud Reza Jaafari
Jul 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beibei BieZongfang Li
Dec 13, 2017·Archives of Pharmacal Research·Yumeng WeiLing Zhao
Feb 20, 2018·The Journal of Allergy and Clinical Immunology. in Practice·Kyoung-Hee SohnHye-Ryun Kang
Apr 27, 2018·Acta Biochimica Et Biophysica Sinica·Libin SongLuming Liu
May 1, 2018·Journal of Cardiovascular Medicine·Christian Cadeddu DessalviGiuseppe Mercuro

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