Co-distribution of the cannabinoid CB1 receptor and the 5-HT transporter in the rat amygdale

European Journal of Pharmacology
John C AshtonPaul F Smith

Abstract

Cannabis sometimes causes dysphoria rather than euphoria; however, evidence relating to the interaction between the cannabinoid and 5-hydroxtryptamine (5-HT) systems is limited, especially in areas of the brain such as the amygdale. Here we report that cannabinoid CB(1) receptors and 5-HT transporter proteins are co-distributed in the amygdale, suggesting the possibility that activation of cannabinoid CB(1) receptors might cause a reduction in 5-HT release, similar to its effect on other neurotransmitters, thereby resulting in dysphoria.

References

Dec 29, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·D DeasJ Hazy

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Citations

Jan 29, 2016·Brain Research·Mohammad NasehiMohammad-Reza Zarrindast
Oct 13, 2007·European Journal of Pharmacology·Thorsten Lau, Patrick Schloss

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