Co-encapsulation of imiquimod and copaiba oil in novel nanostructured systems: promising formulations against skin carcinoma

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Cristina G VenturiniSilvia S Guterres

Abstract

In this study, two types of cutaneous-directed nanoparticles are proposed for the co-encapsulation of imiquimod (a drug approved for the treatment of basal cell carcinoma) and copaiba oil (oil that exhibits anti-proliferative properties). Nanostructured copaiba capsules (NCCImq) were prepared using the interfacial deposition method, and nanostructured Brazilian lipids (NBLImq) were prepared by high-pressure homogenization. The formulations exhibited average diameter, zeta potential, pH and drug content of approximately 200nm, -12mV, 6 and 1mgmL(-1), respectively. In addition, the formulations exhibited homogeneity regarding particle size, high encapsulation efficiency and stability. Both nanocarriers controlled imiquimod release, and NBLImq exhibited slower drug release (p < 0.05), likely due to increased interaction of the drug with the solid lipid (cupuaçu seed butter). The in vitro evaluation of the imiquimod-loaded nanocarriers was performed using healthy skin cells (keratinocytes, HaCaT); no alteration was observed, suggesting the biocompatibility of the nanocarriers. In addition, in vitro skin permeation/penetration using pig skin was performed, and NCCImq led to increased drug retention in the skin layers and reduced amo...Continue Reading

References

Feb 23, 1999·Pharmaceutical Development and Technology·J L CholletM A Tomai
Aug 7, 2003·Journal of the National Cancer Institute·Margarete SchönMichael P Schön
Nov 5, 2003·Phytotherapy Research : PTR·Sylvia R M LimaPatricia D Fernandes
Jul 26, 2006·Skin Pharmacology and Physiology·M-H Schmid-Wendtner, H C Korting
Aug 3, 2006·The British Journal of Dermatology·B A RaaschC Garbe
Nov 23, 2006·International Journal of Pharmaceutics·S Daoud-MahammedR Gref
Jul 28, 2007·Nature Clinical Practice. Oncology·Julie A NevilleDavid J Leffell
May 15, 2009·International Journal of Pharmaceutics·Sarah KüchlerMonika Schäfer-Korting
Oct 15, 2009·International Journal of Pharmaceutics·C E Mora-HuertasA Elaissari
Jan 9, 2010·Journal of Biomedical Nanotechnology·Karina PaeseSílvia S Guterres
Apr 23, 2010·Expert Opinion on Pharmacotherapy·Giuseppe MicaliMaria Rita Nasca
Jul 20, 2010·International Journal of Pharmaceutics·Pallavi V Pople, Kamalinder K Singh
Aug 20, 2010·Colloids and Surfaces. B, Biointerfaces·E Gonzalez-MiraE B Souto
May 12, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mona M A Abdel-MottalebAlf Lamprecht
May 25, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M C FontanaR C R Beck
Jul 19, 2011·Colloids and Surfaces. B, Biointerfaces·Joana AraújoMaria L Garcia
Jul 23, 2011·Advanced Drug Delivery Reviews·Shrinivas VenkataramanYi Yan Yang
Dec 20, 2011·Toxicology and Applied Pharmacology·Sumit AroraKishore M Paknikar
Mar 27, 2012·Photochemistry and Photobiology·Cassia Britto DetoniSilvia Stanisuaski Guterres
Jun 6, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Surajit DasReginald B H Tan
Jun 8, 2012·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ana Luiza M da SilvaSilvia S Guterres
Nov 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Holbrook Kohrt
Apr 9, 2013·Colloids and Surfaces. B, Biointerfaces·Xin GuGuolin Wu
May 21, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Željka Vanić, Nataša Škalko-Basnet
Dec 18, 2013·The Lancet Oncology·Fiona Bath-HextallUNKNOWN Surgery versus Imiquimod for Nodular Superficial basal cell carcinoma (SINS) study group
Mar 13, 2014·International Journal of Nanomedicine·Renata V ContriSilvia S Guterres
Apr 17, 2014·Journal of Biomedical Nanotechnology·Renata V ContriSilvia S Guterres
May 17, 2014·Journal of the American Academy of Dermatology·Giuseppe MicaliRobert A Schwartz
Jun 28, 2014·International Journal of Nanomedicine·Márcia Camponogara FontanaRuy Carlos Ruver Beck
Sep 4, 2015·Journal of Nanoscience and Nanotechnology·Janaíne Micheli ChassotLetícia Cruz

❮ Previous
Next ❯

Citations

Jan 9, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fernanda C FloresCristiane B Silva
Sep 7, 2017·AAPS PharmSciTech·Graziela Scheuer GomesSandra Elisa Haas
Jun 21, 2020·Drug Delivery and Translational Research·R P GazziSilvia S Guterres
Apr 27, 2019·Frontiers in Oncology·Julieti Huch BussFabiana Kömmling Seixas
Jun 25, 2019·Current Medicinal Chemistry·Bruno Fonseca-SantosMarlus Chorilli
Dec 26, 2018·Expert Opinion on Drug Delivery·Mandeep SharmaO P Katare
Sep 7, 2020·International Journal of Pharmaceutics·Akmal H SabriMaria Marlow
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Talita Pizza Anunciato CasariniSilvia Stanisçuaski Guterres
Jan 26, 2021·Frontiers in Cellular and Infection Microbiology·Lígia Nunes de Morais RibeiroBelchiolina Beatriz Fonseca
Aug 2, 2021·Methods : a Companion to Methods in Enzymology·Ana Luiza LimaGuilherme M Gelfuso
Jul 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Flavia Rodrigues da SilvaPaula Santos Nunes
May 3, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marina França DiasArmando Silva Cunha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.