Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor.

PloS One
Chiyu ZhangLi Wu

Abstract

Cross-species transmission and adaptation of simian immunodeficiency viruses (SIVs) to humans have given rise to human immunodeficiency viruses (HIVs). HIV type 1 (HIV-1) and type 2 (HIV-2) were derived from SIVs that infected chimpanzee (SIVcpz) and sooty mangabey (SIVsm), respectively. The HIV-1 restriction factor SAMHD1 inhibits HIV-1 infection in human myeloid cells and can be counteracted by the Vpx protein of HIV-2 and the SIVsm lineage. However, HIV-1 and its ancestor SIVcpz do not encode a Vpx protein and HIV-1 has not evolved a mechanism to overcome SAMHD1-mediated restriction. Here we show that the co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in SIVcpz and HIV-1. We found evidence for positive selection of SAMHD1 in orangutan, gibbon, rhesus macaque, and marmoset, but not in human, chimpanzee and gorilla that are natural hosts of Vpx-negative HIV-1, SIVcpz and SIVgor, respectively, indicating that vpx drives the evolution of primate SAMHD1. Ancestral host state reconstruction and temporal dynamic analyses suggest that the most recent common ancestor of SIVrcm, SIVmnd, SIVcpz, SIVgor and HIV-1 was a SIV that had a vpx gene; however, the vpx gene of SIVcpz was lost approximately 36...Continue Reading

References

Dec 13, 2002·Journal of Virology·Arman A BashirovaMary Carrington
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Philippe LemeyAnne-Mieke Vandamme
Jun 14, 2003·Science·Elizabeth BailesPaul M Sharp
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Dec 9, 2003·Trends in Biochemical Sciences·Chongwoo A Kim, James U Bowie
Nov 2, 2004·Nature Reviews. Immunology·Reuben S Harris, Mark T Liddament
Feb 4, 2005·Molecular Biology and Evolution·Ziheng YangRasmus Nielsen
Nov 10, 2006·Nature·Fran Van HeuverswynMartine Peeters
May 8, 2007·Molecular Biology and Evolution·Ziheng Yang
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
May 10, 2008·Journal of Molecular Evolution·André E R SoaresCarlos G Schrago
Jul 16, 2008·Annual Review of Genetics·Daniel Wolf, Stephen P Goff
May 5, 2009·PLoS Computational Biology·Joel O Wertheim, Michael Worobey
Sep 26, 2009·PLoS Computational Biology·Philippe LemeyMarc A Suchard
Feb 18, 2010·PLoS Biology·Michael Emerman, Harmit S Malik
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul M Sharp, Beatrice H Hahn
Aug 7, 2010·Trends in Microbiology·David T EvansJohn C Guatelli
Sep 18, 2010·Science·Michael WorobeyPreston A Marx
Jun 23, 2011·PLoS Pathogens·Martha I NelsonMarie Gramer
Jul 12, 2011·Retrovirology·Corine St Gelais, Li Wu
Oct 18, 2011·Cell·Nicolas Manel, Dan R Littman
Nov 3, 2011·Molecular Biology and Evolution·Joel O WertheimSergei L Kosakovsky Pond
Dec 20, 2011·Trends in Immunology·Nadine Laguette, Monsef Benkirane
Dec 27, 2011·Trends in Genetics : TIG·Robert J Gifford

❮ Previous
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Citations

Sep 8, 2012·Future Microbiology·Zhangming ChenSongcheng Ying
Oct 6, 2012·Retrovirology·Herwig KoppensteinerMichael Schindler
Oct 9, 2012·The Journal of Biological Chemistry·Reuben S HarrisDavid T Evans
Nov 14, 2013·Retrovirology·Alberto Brandariz-NuñezFelipe Diaz-Griffero
Sep 29, 2012·Zoological Research·Pei-Lu LiChi-Yu Zhang
Jan 19, 2016·Biochemical and Biophysical Research Communications·Jian KangJuan Du
Oct 29, 2013·Journal of Molecular Biology·Alexandre SzeJohn Hiscott
Jul 23, 2013·The EMBO Journal·Jan RehwinkelCaetano Reis e Sousa
Nov 20, 2012·Virology·Tommy E WhiteFelipe Diaz-Griffero
Sep 10, 2014·Biochemical and Biophysical Research Communications·Changzhong JinNanping Wu
Jul 11, 2014·Virology·Tommy E WhiteFelipe Diaz-Griffero
Jan 28, 2014·PloS One·Susan V WestmorelandRonald C Desrosiers
Jan 22, 2013·Biology·Rajesh ThippeshappaJason T Kimata
Nov 28, 2017·Frontiers in Immunology·Jenna M AntonucciLi Wu
Aug 29, 2012·Nature Reviews. Microbiology·Diana AyindeOlivier Schwartz
Mar 13, 2017·The Journal of General Virology·Minami YamamotoMikako Fujita
Jun 2, 2020·Frontiers in Microbiology·Rajesh ThippeshappaDeepak Kaushal
Mar 18, 2019·Medical Microbiology and Immunology·Catharina MajerRenate König
Apr 5, 2020·Viruses·Si'Ana A CogginsBaek Kim

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Datasets Mentioned

BETA
AAH36450.1
JQ085411

Methods Mentioned

BETA
PCR

Software Mentioned

new
TreeAnnotator
PAML
mrbayes
MEGA5
codeML
BEAST
Hon
Anc
Muscle

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