Co-existence of alternative forms of 8q gain in cytogenetic clones of three patients with acute myeloid leukemia, pointing to 8q22 approximately 8qter as a region of biologic significance

Cancer Genetics and Cytogenetics
J R BatanianB Gadre

Abstract

Clonal trisomy 8 chromosome abnormalities can be detected in 15% of patients with acute myeloid leukemia (AML). The most common form of change is complete gain of the whole chromosome 8, followed by partial gains in unbalanced forms. The biologic consequences of trisomy 8 remain unclear, but a gene dosage effect is suspected. We report on three patients with AML who had alternative forms of chromosome 8 gain in their bone marrow cells. The partial gains resulted from a breakpoint in the chromosome band 8q22. This indicates that the region 8q22 to 8qter may be of particular pathogenetic importance.

References

Jul 1, 1992·Genes, Chromosomes & Cancer·F Mitelman, S Heim
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Mar 1, 1997·Cancer Genetics and Cytogenetics·J DierlammD K Hossfeld
Jan 15, 1998·Cancer Genetics and Cytogenetics·Y L Kwong, T K Chan
Jan 5, 2000·Cancer Genetics and Cytogenetics·M B QumsiyehX X Zhang

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Citations

Apr 24, 2004·Cancer Genetics and Cytogenetics·Carol T HenkleConstance A Griffin
Nov 1, 2006·Prenatal Diagnosis·Christelle GolzioHeather C Etchevers

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