Co-existence of leukoderma with features of Dowling-Degos disease: reticulate acropigmentation of Kitamura spectrum in five unrelated patients

Dermatology : International Journal for Clinical and Investigative Dermatology
G G LestringantI H Galadari

Abstract

The spectrum of Dowling-Degos disease-reticulate acropigmentation of Kitamura (DDD-RAK) is a group of rare autosomal dominant disorders that have in common a unique histological picture of hyperpigmented digitate epidermal 'downgrowths'. Patients with the DDD-RAK spectrum may show hyperpigmented macules and papules, facial pits, breaks in dermatoglyphics and epidermoid cysts. We examined 5 unrelated patients, 3 females and 2 males (age range 22-35 years), who presented with clinical and histological features of the DDD-RAK spectrum. In addition, the patients presented with hypo- or depigmented macules and papules. Histopathology of the lesions revealed features that were identical to DDD-RAK; there were, however, diminution or absence of pigmentation. Family histories for pigmented lesions and leukoderma were positive in all patients and consistent with autosomal dominant modes of inheritance. These 5 cases, together with isolated reports in the literature of achromic lesions with histological features of DDD-RAK, point to the hypothesis that achromic macules and papules may be a feature of the DDD-RAK spectrum.

Citations

Sep 5, 2002·International Journal of Dermatology·Khalid Al HawsawiDaifullah Al Aboud
Dec 21, 2012·Indian Journal of Dermatology, Venereology and Leprology·Kabir SardanaShikha Chugh
Sep 5, 2013·Annals of Dermatology·Jade Wititsuwannakul, Nopadon Noppakun
Apr 1, 2006·The Journal of Investigative Dermatology·Cheng-Rang LiLin He
Jul 20, 2007·Journal of the American Academy of Dermatology·Yu-Hung Wu, Yang-Chih Lin
Apr 21, 2004·Journal of the American Academy of Dermatology·Wiete Westerhof, Koert P Dingemans
Jun 23, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·A W ArnoldC Has
May 15, 2008·The Journal of Dermatology·Füsun ArdaAli Tahsin Güneş
Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·C-R LiB Wang
May 18, 2021·Molecular and Cellular Biochemistry·Salim M A BastakiShreesh Ojha

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