Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children

Diabetologia
S CaprioW V Tamborlane

Abstract

To determine the time course of changes in insulin action and secretion that occur early during the development of obesity, we studied children before the onset of puberty. The reason for choosing the prepubertal stage of development is that it is metabolically characterized by both a high sensitivity to insulin and low glucose stimulated insulin responses. Fifteen obese preadolescents (8 male/7 female, age 10 +/- 0.4 years, body mass index (BMI) 31 +/- 1.2 kg/m2 Tanner Stage I) with a duration of obesity of less than 5 years and 10 non-obese preadolescents (6 male/4 female, age 10 +/- 0.4 years, BMI 18 +/- 0.9 kg/m2) matched for gender were studied. In a cross-sectional analysis, we compared responses in obese preadolescents, with those in obese adolescents and obese adults with a longer duration of obesity. The euglycaemic hyperinsulinaemic clamp with 1-13C-glucose (Hot Ginf) and indirect calorimetry were used to quantitate insulin action and the hyperglycaemic clamp used to assess beta-cell function. Insulin-stimulated glucose uptake measured at two physiological levels of hyperinsulinaemia (approximately 180 and 480 pmol) was reduced by 20 and 45% in all three groups of obese compared to non-obese subjects (p < 0.01). Defec...Continue Reading

Citations

Sep 21, 2007·Calcified Tissue International·J Antonio Bermudez de la VegaRamón Pérez-Cano
Apr 12, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Y Sakurai
Feb 27, 2001·Progress in Pediatric Cardiology·J Steinberger
Jul 27, 2011·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Laura L HaymanLynne T Braun
Oct 17, 1998·Breast Cancer Research and Treatment·B A Stoll
May 13, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S ShalitinM Phillip
Jan 12, 2000·Journal of Pediatric Gastroenterology and Nutrition·M Rashid, E A Roberts
Jan 5, 2002·Advances in Anatomic Pathology·Melissa J Contos, Arun J Sanyal
Jun 18, 2011·The Journal of Cardiovascular Nursing·Laura L HaymanLynne T Braun
Sep 8, 2012·The Journal of Cardiovascular Nursing·Kathy BerraNancy Houston Miller
Aug 13, 2013·PloS One·Melania MancoGiuseppe Stefano Morino
Aug 30, 2008·Endocrine Journal·Keiko AraiUNKNOWN Japan Diabetes Clinical Data Management Study Group
Jun 1, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Carmen S MazzaMaría Beatriz Araujo
Mar 28, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Doris TahaSalvador Castells
Sep 26, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sibel Tulgar KinikKürşad Tokel
Jul 29, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Cihan MeralTeoman Dogru
Feb 27, 2007·Vascular Health and Risk Management·Courtney J Jolliffe, Ian Janssen
Oct 2, 2009·Journal of Endocrinological Investigation·N SantoroE Miraglia del Giudice
Oct 2, 2009·Journal of Endocrinological Investigation·S PiliaS Loche
Sep 23, 2008·European Journal of Endocrinology·Francesco Chiarelli, Maria Loredana Marcovecchio
Mar 20, 2013·Cellular and Molecular Life Sciences : CMLS·Seogang Hyun
Jan 24, 2013·European Journal of Pediatrics·Despina HerouviKyriaki Karavanaki
Sep 30, 2006·Hormone Research·Ingrid M Libman, Silva A Arslanian
Jan 30, 2016·Progress in Pediatric Cardiology·Charles W Shepard, Julia Steinberger
Oct 1, 2004·Journal of the American Academy of Nurse Practitioners·Diane BerryMargaret Grey
Mar 25, 2005·Pediatric Diabetes·Thomas ReinehrUNKNOWN DPV-Wiss Study Group
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Joanna KoenigsbergBonita Falkner
Oct 28, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J AucouturierB W Timmons
May 15, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Atsushi NishiyamaMasafumi Matsuo
Dec 6, 2005·Metabolism: Clinical and Experimental·Rosario MartosVíctor Sánchez-Margalet
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Francine Ratner Kaufman
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R Alemzadeh
Sep 17, 2011·The Journal of Pediatrics·Julia SteinbergerK Scott Baker
Sep 29, 2004·Diabetes Care·Arcangelo IannuzziMaurizio Trevisan
Jun 24, 2016·Journal of Pediatric Gastroenterology and Nutrition·William W WongElliot O'Brian Smith
Dec 28, 1999·Endocrinology and Metabolism Clinics of North America·S Caprio, W V Tamborlane
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J N RoemmichA D Rogol
Jan 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M ValleA Suanes
Feb 20, 2018·BioMed Research International·Jinkyung ChoHyunsik Kang

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