PMID: 2500772Jan 1, 1989Paper

Co-existence of two aneuploid stemlines in benign adenomas. A report of three cases with stemline heterogeneity

Virchows Archiv. A, Pathological Anatomy and Histopathology
H JoensuuK A Alanen

Abstract

The co-existence of 2 or more aneuploid stemlines (DNA multiploidy) has been described in malignant human neoplasms and such cancers have often been found to be associated with a poor prognosis. Here 3 benign human adenomas with 2 co-existing aneuploid stemlines are described. Despite DNA stemline heterogeneity and large DNA indices up to 2.8 none of the adenomas recurred or gave rise to metastases after a simple excision during the follow-up of 8, 10 and 11 years. Two adenomas were hormonally active. Marked cellular atypia and frequent mitoses were seen in 1 of the adenomas but the other 2 tumours had little atypia. The present cases indicate that DNA stemline heterogeneity may occur in benign adenomas, and not even the presence of 2 aneuploid stemlines with greatly increased nuclear DNA content can be regarded as a conclusive sign of malignancy.

References

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·T MattfeldtG Feichter
Jul 15, 1986·Cancer·W HiddemannE Grundmann
Jan 1, 1985·Pathology, Research and Practice·T BüchnerA Roessner
Nov 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D W HedleyE A Musgrove
Apr 15, 1984·Cancer·M AnnikoJ Wersäll
Jun 1, 1984·The Journal of Investigative Dermatology·W StenzingerJ Schumann

❮ Previous
Next ❯

Citations

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·H FeichtingerG Mikuz
Sep 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Takahiro IsakaDavid C Allison
Jun 1, 1992·Endocrine Pathology·Ingrid Zbieranowski, David Murray
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·B C PadbergS Schröder
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·S Díaz-CanoH Galera-Davidson
Jul 15, 1994·Cancer Genetics and Cytogenetics·M E HerrmannP A Lalley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.