Co-exposure of metals and high fat diet causes aging like neuropathological changes in non-aged mice brain

Brain Research Bulletin
Ghazala Iqbal, Touqeer Ahmed

Abstract

In recent decades, humans' exposure to metals have increased due to industrialization and socioeconomic trends have caused increased high fat diet (HFD) consumption. Concurrently, metals and HFD are risk factors for health, and in particular, the cognitive impairment. The aim of this study was to evaluate the effect of metals and HFD treatment on neuropathological changes in young mice brain, and compare with untreated young mice (8-11 weeks = 2-3 months) and aged mice (12 months). Mice were given 300 ppm of Aluminum (Al), Copper (Cu), Lead (Pb) and Cadmium (Cd) in drinking water and HFD feed (40% of the feed weight was animal fat) for 42 days. Metals+HFD treated mice were subjected to behavior tests, such as, Morris water maze, elevated plus maze, fear condition and contextual memory to evaluate memory levels. Spatial memory (p < 0.01), contextual memory (p < 0.01) and fear memory (p < 0.05) were significantly impaired in metals+HFD group compared to young mice. The extent of neurodegeneration with metals+HFD co-exposure was considerably high in hippocampus (p < 0.01) and cortex (p < 0.01), compared to aged mice brain and untreated young mice. Increased oxidative stress was recorded in the cortex, hippocampus and amygdala of m...Continue Reading

Citations

Dec 9, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Antonina A ShumakovaIvan V Gmoshinski
Sep 29, 2020·Toxicology Reports·John C MazzoccoJonathan H Freedman
Apr 20, 2021·Environmental Epidemiology·Whitney CowellRosalind J Wright

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