Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish

The Science of the Total Environment
Qin WuGuangyu Li

Abstract

Owing to the eutrophication in freshwater and industrial emissions, the detected concentrations of MCLR and nano-TiO2 in nature water increase year by year. The purpose of this study was to evaluate the joint effect of microcystin-LR (MCLR) and titanium dioxide nanoparticles (nano-TiO2) on the zebrafish brain and to investigate the underlying mechanisms. In this study, four-month old zebrafish were exposed to 0, 0.5, 4, and 32 μg/L MCLR and MCLR-co-nano-TiO2 (100 μg/L) for 45 days. Obvious brain injury characterized by formation of glial scars and ventriculomegaly was observed in both MCLR groups and MCLR-co-nano-TiO2 groups. In addition, our results showed the existence of nano-TiO2 aggravated MCLR-induced abnormity of swimming behavior and social behavior of zebrafish. To clarify the mechanisms of nano-TiO2 aggravated MCLR-induced brain injury, we firstly examined the reactive oxygen species (ROS) generation in the zebrafish brain. The results showed that co-exposure with nano-TiO2 could further increase ROS content compared with MCLR only groups. We also detected a significant change of lipid peroxidation products (MDA, malondialdehyde) content, antioxidant enzyme (SOD, superoxide dismutase) activity, and non-enzymatic antio...Continue Reading

Citations

Feb 3, 2021·Journal of Applied Toxicology : JAT·Lin Liu, Lu Kong
Aug 18, 2020·Toxicon : Official Journal of the International Society on Toxinology·Qing CaoLiuyan Yang
Jun 22, 2020·Ecotoxicology and Environmental Safety·Zengjin WangBing Yan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.