Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Kunio ArakiHisao Ito

Abstract

Cyclooxygenase (Cox)-2 plays an important role in cell proliferation, carcinogenesis and tumor growth, in part through the synthesis of prostaglandin E2 (PGE2) as well as through other yet unknown routes. Epidermal growth factor receptor (EGFR) signaling regulates Cox-2 expression, which has not been thoroughly examined in bronchial carcinomas. The current study examined the expression of Cox-2, EGFR, P53 and proliferative marker Ki-67 immunoreactivities by immunohistochemistry in 71 surgically removed stage I bronchial adenocarcinomas. Furthermore, we evaluated the prognostic value of these molecules to elucidate the biological significance of Cox-2 expression. Higher Cox-2 expression (more than 10% immunoreactivities in tumor cells) was strongly associated with higher EGFR and P53 expression as well as a Ki-67 LI above 20% (P < 0.01). Cox-2 and EGFR immunoreactive tumor cells showed a similar distribution pattern. Five-year survival rate was 73% in 57 cases showing higher Cox-2 expression and 100% in 14 cases showing lower expression, indicating a significant difference in survival (P = 0.040). Higher Cox-2 expression might be associated with tumor progression and worse prognosis through EGFR signaling interaction in Stage I ...Continue Reading

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Citations

Apr 1, 2005·Pathology Oncology Research : POR·László Kopper, József Tímár
Feb 7, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hao JiangWei Zhao
Jul 24, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomohiro HarukiHisao Ito
Jan 16, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shinji FujiokaHisao Ito
Sep 23, 2006·Expert Opinion on Investigational Drugs·Piotr Smolewski

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