PMID: 6965613Feb 1, 1980Paper

Co-expression of differentiation markers in hybrids between Friend cells and lymphoid cells and the influence of the cell shape

Cell
M Allan, P R Harrison

Abstract

We have studied the regulation of differentiation within the hemopoietic system by fusing mouse Friend cells (which can be induced to undergo red blood cell differentiation) to various mouse lymphomas and myelomas which express characteristic T and B lymphocytes surface antignes. Our results show that both erythroid and lymphoid differentiation markers can be co-expressed within the same cell. To determine whether this result applies to other differentiation states, we fused suspension Friend cells to three adherent fibroblast cell lines, and isolated both adherent and suspension hybrids. In fact, suspension hybrid clones were inducible for hemoglobin, whereas adherent clones were not. No obvious differences in overall chromosome balance were evident between the adherent and suspension hybrids. A similar correlation between suspension morphology and inducibility of hemoglobin was found in hybrids between suspension Friend cells and an adherent lymphoma line. These results show that different developmental programs can be co-expressed within the same hybrid cell; but the strongly adherent type of morphology is inconsistent with expression of the red blood cell phenotype, both in hybrid cells derived entirely from hemopoietic par...Continue Reading

References

Sep 1, 1976·Cell·R A Miller, F H Ruddle
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S H OrkinP Leder
Mar 1, 1977·Somatic Cell Genetics·J F ConscienceG J Darlington
May 1, 1977·Somatic Cell Genetics·G KöhlerC Milstein
May 19, 1971·Nature: New Biology·P CoffinoM D Scharff
Feb 23, 1972·Nature: New Biology·J MinnaM Nirenberg
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J A Peterson, M C Weiss
Apr 1, 1972·Journal of Cellular Physiology·R Bertolotti, M C Weiss
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J A Schneider, M C Weiss
Jun 1, 1973·Bacteriological Reviews·F M Davis, E A Adelberg
Jan 1, 1974·Annual Review of Genetics·R L Davidson
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J MinnaM Nirenberg

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Citations

Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·J Zeuthen
Jan 1, 1987·Archives of Virology·C AmiciA Benedetto
Jul 1, 1981·Experimental Cell Research·A BenedettoM G Santoro
Jan 1, 1980·Journal of Immunological Methods·T M Dexter, N G Testa
Aug 1, 1985·Molecular and Cellular Endocrinology·C L Bethea, S L Kozak
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S LinderN R Ringertz
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I Greiser-WilkeJ F Conscience
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A Ben-Ze'ev, A Amsterdam
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F M WattC H O'Neill
Jan 1, 1981·Hybridoma·G Köhler
May 1, 1982·Experimental Cell Research·S Junker
Feb 1, 1981·Experimental Cell Research·M McBurneyM Featherstone
May 1, 1989·The Journal of Experimental Zoology·J R Whittaker, T H Meedel
Jan 15, 1989·International Journal of Cancer. Journal International Du Cancer·A GreenbergR Laskov
Nov 7, 1982·Journal of Theoretical Biology·M J BissellG Parry
Sep 1, 1994·Molecular and Cellular Biology·H Gourdeau, P R Walker
Dec 1, 1984·Experimental Cell Research·P R Harrison
Jun 1, 1987·Experimental Cell Research·M A VenturaP Thomopoulos

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