Abstract
Hepatocyte growth factor acts differently depending on the organs or tumours involved. It may be produced simultaneously with its receptor, c-Met, in several types of malignant tumour cells and may exercise an autocrine regulation. To analyse the effect of hepatocyte growth factor in human prostate cancer, we conducted immunohistochemistry, in situ hybridization and the reverse transcriptase polymerase chain reaction. The first two techniques revealed the growth factor in prostate cancer cells, and the polymerase chain reaction confirmed this expression. c-Met is expressed in prostate cancer cells, but not in interstitial cells. Hepatocyte growth factor is expressed in interstitial cells, especially in hormone-treated cancer tissue, indicating that the growth factor pathway changes with the hormonal status. Low-grade tumours expressed c-Met at the plasma membrane. Higher grade tumours tended to express it in the cytoplasm, suggesting that the role of c-Met as the hepatocyte growth factor receptor was blocked in higher grade tumours. The relationship between the growth factor and its receptor is thus influenced by hormonal status and differentiation in prostate cancer and is not explained simply in terms of autocrine or paracrin...Continue Reading
Citations
Jan 5, 2000·The Prostate·D Djakiew
May 27, 1999·The Prostate·K S KoenemanL W Chung
Jan 28, 2005·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·F Comhaire, A Mahmoud
Nov 21, 2008·The Prostate·Kenji YasudaHideki Fuse
May 1, 2001·Pathology International·G EdakuniK Miyazaki
Jul 28, 2006·BMC Cancer·Amanda TateMagnus Edlund
Apr 15, 2004·British Journal of Cancer·D MasuyaH Yokomise
Feb 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Osamu AmanoShoichi Iseki
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Sep 30, 2010·Cancer Research·Dazhi YangPeter M Blumberg
Jul 28, 2004·The American Journal of Pathology·Koh-Ichi NakashiroRyoichi Oyasu
Jan 11, 2000·Urology·X Zhu, P A Humphrey
Jul 12, 2005·European Urology·Osamu NagakawaHideki Fuse
May 30, 2006·Clinical Genitourinary Cancer·Peter A HumphreyPhilip W Kantoff