Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.

Cellular Oncology : the Official Journal of the International Society for Cellular Oncology
Guido ValenteCiro Isidoro

Abstract

Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of Plex-B1, either alone or in association with Met, can be of predictive value for tumour progression. The expression and distribution of Plex-B1 and Met were investigated by immunohistochemistry and immunofluorescence in 50 human neoplasias originating in the breast and ovary, and correlated with clinical-pathological data at diagnosis. Plex-B1 and Met were individually expressed in 14% and in 24% of the tumours, respectively. Plex-B1 and Met were co-expressed in 24/50 cases (48%), and in the majority of these (83%) Met was tyrosine phosphorylated. The expression of Plex-B1 or Met alone showed no significant correlation with tumour aggressiveness, whereas advanced stage tumours (III-IV) frequently showed Plex-B1-Met double-positive (9/13). Tumours co-expressing Plex-B1 and Met were characterised by worse grading and higher incidence of lymph node metastases. Out of 22 tumours with lymph node metastases, as many as 19 were Plex-B1 and Met double-...Continue Reading

Citations

Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·Gera NeufeldOfra Kessler
Nov 10, 2010·BMC Cancer·Shuangmei YeShixuan Wang
Dec 22, 2019·Cells·Magali WilliamsonClaire M Wells
Apr 1, 2021·International Reviews of Immunology·Elena Kuklina

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