Co-Expression of the Epstein-Barr Virus-Encoded Latent Membrane Proteins and the Pathogenesis of Classic Hodgkin Lymphoma

Cancers
Katerina VrzalikovaPaul G Murray

Abstract

The Epstein-Barr virus (EBV) is present in the tumour cells of a subset of patients with classic Hodgkin lymphoma (cHL), yet the contribution of the virus to the pathogenesis of these tumours remains only poorly understood. The EBV genome in virus-associated cHL expresses a limited subset of genes, restricted to the non-coding Epstein-Barr virus-encoded RNAs (EBERs) and viral miRNA, as well as only three virus proteins; the Epstein-Barr virus nuclear antigen-1 (EBNA1), and the two latent membrane proteins, known as LMP1 and LMP2, the latter of which has two isoforms, LMP2A and LMP2B. LMP1 and LMP2A are of particular interest because they are co-expressed in tumour cells and can activate cellular signalling pathways, driving aberrant cellular transcription in infected B cells to promote lymphomagenesis. This article seeks to bring together the results of recent studies of the latent membrane proteins in different B cell systems, including experiments in animal models as well as a re-analysis of our own transcriptional data. In doing so, we summarise the potentially co-operative and antagonistic effects of the LMPs that are relevant to B cell lymphomagenesis.

References

Feb 23, 1989·The New England Journal of Medicine·L M WeissJ Sklar
Sep 29, 1995·Annals of the New York Academy of Sciences·R KüppersM L Hansmann
Mar 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P J BiermanT C Greiner
Jan 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R KüppersK Rajewsky
Feb 7, 1997·International Journal of Cancer. Journal International Du Cancer·S L GlaserA Claviez
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·W KulwichitN Raab-Traub
Oct 13, 1998·Immunity·G J BabcockD A Thorley-Lawson
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A RowlingsM M Horowitz
Jan 19, 2000·The Journal of Experimental Medicine·B JungnickelR Küppers
Feb 7, 2002·Blood·José I Martín-SuberoReiner Siebert
Mar 27, 2002·International Reviews of Immunology·M MerchantS K Pierce
Dec 13, 2002·International Journal of Cancer. Journal International Du Cancer·Stefan JoosAnna Jauch

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Citations

Aug 27, 2019·Frontiers in Oncology·Claire Shannon-Lowe, Alan Rickinson

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Methods Mentioned

BETA
GTPase
transgenic
transfection

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