Co-expression of the proprotein-processing endoprotease furin and its substrate transforming growth factor beta1 and the differentiation of rat hepatocytes

FEBS Letters
H HoshinoT Takeuchi

Abstract

Furin, a member of the yeast Kex2 endoprotease family, converts a number of proproteins to their active forms. The liver produces a number of proproteins having a furin-cleavable site; thus, furin may be involved in growth and differentiation both in the partially hepatectomized liver and in primary cultured hepatocytes. Furin mRNA levels are elevated in tissues regenerated from partially hepatectomized rat liver. In primary culture of rat hepatocytes, furin expression increases gradually with time, and its expression is greatly enhanced by transforming growth factor beta1, whose processing from the precursor requires cleavage by furin. Thus, we suggest that the regeneration and differentiation of hepatocytes is dependent upon the co-elevation of furin and transforming growth factor beta1 mRNAs.

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Citations

May 23, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·M NegishiT Takeuchi
Sep 17, 2005·Molecular Carcinogenesis·Daniel E BassiAndres J P Klein-Szanto
Oct 22, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fernand-Pierre GendronNathalie Rivard
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J LeitleinM Platten
Nov 7, 2016·Cell Communication and Signaling : CCS·María Fernanda Izaguirre, Victor Hugo Casco
Jun 14, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yan ChenXiao-Mou Peng
Dec 9, 2010·International Journal of Cancer. Journal International Du Cancer·Liyuan TianYaping Tian

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