Co-induction of long-term potentiation and long-term depression at a central synapse in the leech

Neurobiology of Learning and Memory
Brian D Burrell, Qin Li

Abstract

Most studies of long-term potentiation (LTP) have focused on potentiation induced by the activation of postsynaptic NMDA receptors (NMDARs). However, it is now apparent that NMDAR-dependent signaling processes are not the only form of LTP operating in the brain [Malenka, R. C., & Bear, M. F. (2004). LTP and LTD: An embarrassment of riches. Neuron, 44, 5-21]. Previously, we have observed that LTP in leech central synapses made by the touch mechanosensory neurons onto the S interneuron was NMDAR-independent [Burrell, B. D., & Sahley, C. L. (2004). Multiple forms of long-term potentiation and long-term depression converge on a single interneuron in the leech CNS. Journal of Neuroscience, 24, 4011-4019]. Here we examine the cellular mechanisms mediating T-to-S (T-->S) LTP and find that its induction requires activation of metabotropic glutamate receptors (mGluRs), voltage-dependent Ca(2+) channels (VDCCs) and protein kinase C (PKC). Surprisingly, whenever LTP was pharmacologically inhibited, long-term depression (LTD) was observed at the tetanized synapse, indicating that LTP and LTD were activated at the same time in the same synaptic pathway. This co-induction of LTP and LTD likely plays an important role in activity-dependent re...Continue Reading

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Citations

Aug 7, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Qin Li, Brian D Burrell
Aug 31, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Qin Li, Brian D Burrell
Jul 15, 2011·The Journal of Experimental Biology·Kathryn B Grey, Brian D Burrell
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maxim BazhenovBrian H Smith
Sep 28, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ying-Zu HuangWen-Li Chuang
Mar 14, 2008·Journal of Neurophysiology·Kathryn B Grey, Brian D Burrell
Jul 10, 2019·NPJ Science of Learning·Wickliffe C AbrahamDavid L Glanzman
May 23, 2021·Biochemical and Biophysical Research Communications·Adam R Gold, David L Glanzman

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