Co-infection of scrub typhus and leptospirosis in patients with pyrexia of unknown origin in Longding district of Arunachal Pradesh in 2013

Indian Journal of Medical Microbiology
Biswajyoti BorkakotyJagadish Mahanta

Abstract

Scrub typhus and leptospirosis are bacterial zoonotic disease causing high morbidity and mortality. The seasonal outbreak of pyrexia is common in Arunachal Pradesh (AP); many times the disease remains undiagnosed. An outbreak of pyrexia of unknown origin (PUO) occurred in Longding district of Arunachal Pradesh in 2013, with 108 deaths, which was investigated to elucidate the cause of illness. Blood samples from the affected region with acute pyrexia were collected, and screened for the malaria parasite, scrub typhus IgM and leptospira IgM. Scrub typhus IgM was reactive in 97% (30/31), and 25% (8/31) cases were co-infected with leptospira. Incidentally, scrub typhus reactive (67%) and leptospira co-infection (62.7%) were higher in females. Record of previous 3 years (2011-2013) from Longding, Community Health Centre showed an increase in indoor pyrexia cases by 2-fold or more during October and November. The present study is the first report of co-infection of scrub typhus with leptospirosis from Northeast India. Medical officers in this region should take scrub typhus and leptospirosis in their differential diagnosis of patients with PUO for early diagnosis and effective treatment.

References

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Citations

Aug 19, 2016·Vector Borne and Zoonotic Diseases·Aniruddha JakhariaJagadish Mahanta
Oct 8, 2016·Infectious Diseases of Poverty·Sunuraj SivarajanRittwick Barman
Nov 4, 2017·PLoS Neglected Tropical Diseases·Guang XuChristine M Arcari
Sep 26, 2017·PLoS Neglected Tropical Diseases·Ana BonellDaniel H Paris
Jul 21, 2020·Emerging Infectious Diseases·Rajendra MandagePragyan Acharya
Nov 20, 2019·Journal of Family Medicine and Primary Care·Vibha MehtaPratima Gupta
Apr 24, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Bidyut Kumar DasPrakash Kumar Sahoo

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