Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Stefan H M GorissenLuc J C van Loon

Abstract

Dietary protein digestion and absorption plays an important role in modulating postprandial muscle protein synthesis. The impact of co-ingesting other macronutrients with dietary protein on protein digestion and absorption and the subsequent muscle protein synthetic response remains largely unexplored. This study investigated the impact of co-ingesting milk fat with micellar casein on dietary protein-derived amino acid appearance in the circulation and the subsequent postprandial muscle protein synthetic response in healthy older men. Twenty-four healthy, older males (age: 65 ± 1 y, BMI: 25.7 ± 0.5 kg/m2) received a primed continuous infusion of L-[ring-2H5]-phenylalanine and L-[1-13C]-leucine and ingested 20 g intrinsically L-[1-13C]-phenylalanine and L-[1-13C]-leucine-labeled casein with (PRO + FAT; n = 12) or without (PRO; n = 12) 26.7 g milk fat. Plasma samples and muscle biopsies were collected in both the postabsorptive and postprandial state. Release of dietary protein-derived phenylalanine into the circulation increased following protein ingestion (P < 0.001) and tended to be higher in PRO compared with PRO + FAT (Time × Treatment P = 0.076). No differences were observed in dietary protein-derived plasma phenylalanine a...Continue Reading

Citations

Mar 3, 2018·Journal of the International Society of Sports Nutrition·Brad Jon Schoenfeld, Alan Albert Aragon
May 26, 2017·American Journal of Physiology. Endocrinology and Metabolism·Jorn TrommelenLuc J C van Loon
Jan 16, 2019·American Journal of Physiology. Endocrinology and Metabolism·Marlou L DirksLuc J C van Loon
May 22, 2019·American Journal of Physiology. Endocrinology and Metabolism·Andrew M HolwerdaLuc J C van Loon
Nov 16, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N R W GeikerA Astrup
Apr 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Benjamin T WallMarlou L Dirks
Nov 3, 2016·American Journal of Physiology. Endocrinology and Metabolism·Brandon J ShadLeigh Breen
Jan 20, 2019·Sports Medicine·Jorn TrommelenLuc J C van Loon
Sep 14, 2021·Sports Medicine·Philippe J M PinckaersLuc J C van Loon

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