PMID: 16521482Mar 9, 2006Paper

Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Koichi WakabayashiSunao Kaneko

Abstract

The co-localization of amyloid beta (Abeta) and phosphorylated tau in astrocytes in a patient with corticobasal degeneration is described. At autopsy, the present case exhibited neuropathological findings compatible with those of corticobasal degeneration, including atrophy of the frontal and temporal lobes, neuronal loss and gliosis in the cortical and subcortical regions, and presence of cortical ballooned neurons and astrocytic plaques. Moreover, many senile plaques were found in the cerebral cortex. There were also clusters of Abeta-positive granules associated with astrocytic cytoplasm and processes in the subiculum and entorhinal cortex. In the entorhinal cortex, the Abeta-positive granules were occasionally co-localized with phosphorylated tau-positive fibrillary structures in the astrocytic cytoplasm. To our knowledge, this is the first demonstration of co-localization of Abeta and phosphorylated tau in astrocytes. This phenomenon implies that phagocytosis of Abeta coincides with production of phosphorylated tau in the same reactive astrocytes.

References

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Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·D W DicksonUNKNOWN Office of Rare Diseases of the National Institutes of Health
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Jun 3, 2004·Neurobiology of Aging·Robert G NageleJarek Wegiel

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Citations

Nov 11, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaya NagaishiYoichi Nakazato
Dec 18, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Daizo KondoEizo Iseki

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