Abstract
The co-localization of amyloid beta (Abeta) and phosphorylated tau in astrocytes in a patient with corticobasal degeneration is described. At autopsy, the present case exhibited neuropathological findings compatible with those of corticobasal degeneration, including atrophy of the frontal and temporal lobes, neuronal loss and gliosis in the cortical and subcortical regions, and presence of cortical ballooned neurons and astrocytic plaques. Moreover, many senile plaques were found in the cerebral cortex. There were also clusters of Abeta-positive granules associated with astrocytic cytoplasm and processes in the subiculum and entorhinal cortex. In the entorhinal cortex, the Abeta-positive granules were occasionally co-localized with phosphorylated tau-positive fibrillary structures in the astrocytic cytoplasm. To our knowledge, this is the first demonstration of co-localization of Abeta and phosphorylated tau in astrocytes. This phenomenon implies that phagocytosis of Abeta coincides with production of phosphorylated tau in the same reactive astrocytes.
References
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 1, 1989·Journal of Neuropathology and Experimental Neurology·K WatabeS U Kim
Dec 20, 1994·Journal of the Neurological Sciences·K ArimaT Inose
Apr 1, 1994·The Journal of Comparative Neurology·J G BeesonF H Gage
Nov 1, 1996·Acta Neuropathologica·K IkedaK Kosaka
Jan 27, 1997·The Journal of Comparative Neurology·N ChauvetG Alonso
Dec 5, 1997·Acta Neuropathologica·K TsuchiyaH Shimada
May 30, 1998·Acta Neuropathologica·H YamaguchiY Ihara
Apr 30, 1998·Neurobiology of Aging·K IkedaT Nishimura
Oct 31, 1998·Acta Neuropathologica·T KomoriM Iwata
Oct 12, 1999·Brain Pathology·T Komori
Oct 12, 1999·Brain Pathology·L Buée, A Delacourte
Nov 15, 2000·Acta Neuropathologica·D R ThalE Braak
Mar 29, 2001·Acta Neuropathologica·T AraiP L McGeer
Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·D W DicksonUNKNOWN Office of Rare Diseases of the National Institutes of Health
Apr 23, 2003·Brain Research·Robert G NageleHoau-Yan Wang
Jan 6, 2004·Annals of Neurology·Tetsuaki AraiAkihide Mochizuki
Mar 31, 2004·Neuroscience Letters·Yuri UmedaMasato Hasegawa
Apr 8, 2004·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Koichi Wakabayashi, Hitoshi Takahashi
May 5, 2004·Neurobiology of Aging·Christian SchultzHeiko Braak
Jun 3, 2004·Neurobiology of Aging·Robert G NageleJarek Wegiel
Citations
Nov 11, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaya NagaishiYoichi Nakazato
Dec 18, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Daizo KondoEizo Iseki
May 6, 2017·Frontiers in Neuroscience·Anna ChiariniIlaria Dal Prà