Co-localization of the insulin receptor, jun protein and choline acetyltransferase in embryonic chick retina

Experimental Eye Research
V HoldengreberR E Hausman

Abstract

Previous work demonstrated that the availability of insulin to the embryonic chick retina at a critical developmental stage stimulated the activity of the acetylcholine synthetic enzyme, choline acetyltransferase (ChAT) and that this increase required the AP-1 transcription factor, c-jun. Here it is shown that immediately following a 2-5 min exposure to insulin there is, in the amacrine and ganglion cells of the chick embryo retina, a transient increase in the level of jun protein followed by a long-lasting increase in ChAT. These and previous results show that insulin receptor activation is necessary for the characteristic retina developmental increase in ChAT protein and that this increase is preceded by a transient increase in the synthesis of the transcription factor c-jun in the same retina cells. The data demonstrate an intracellular signal transduction pathway from the developmentally-activated insulin receptor through c-jun to ChAT and cholinergic differentiation.

References

Mar 18, 1991·Brain Research. Developmental Brain Research·R E HausmanB H Shah
Jun 22, 1987·The Journal of Comparative Neurology·A W SpiraI G Morgan
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J M KyriakisS W Peterson
Sep 1, 1986·Journal of Neurochemistry·S W PetersonR E Hausman
Jan 1, 1993·Neurochemistry International·M WozniakM K Raizada
Apr 16, 1993·Brain Research. Developmental Brain Research·B H Shah, R E Hausman
Mar 27, 1997·Biochemical and Biophysical Research Communications·Y RenR E Hausman

❮ Previous
Next ❯

Citations

Mar 12, 2002·Clinical & Experimental Ophthalmology·Andrew D GosbellPaula Jablonski
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Fiona R CoulsonAllison D Fryer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Endocrinology and Metabolism : TEM
K A Heidenreich
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
J W Stirling
Clinical & Experimental Ophthalmology
A D GosbellP Jablonski
© 2022 Meta ULC. All rights reserved