Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones

Neuroreport
G UgoliniM Novak

Abstract

Monoclonal antibody MN423 stains all hallmarks of tau neurofibrillary pathology in Alzheimer's disease (AD), without reacting with full-length tau. It recognizes tau molecules which are cleaved at Glu-391, suggesting that tau is endogenously truncated in AD brains. We investigated whether truncation of tau takes place in pre-tangle neurones. Our results showed that tau truncation occurs inside AD neurones in the absence of other signs of AD neurofibrillary pathology. Using in situ end labelling (ISEL) of DNA we found evidence for DNA fragmentation in a significant subpopulation of MN423-positive neurones. Our results therefore suggest that tau truncation is an early intracellular event preceding cell death in AD.

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Citations

Dec 18, 2003·Neurobiology of Disease·Chul-Woong ChungYong-Keun Jung
Mar 18, 2003·Journal of the Neurological Sciences·Katsuji KobayashiYoshifumi Koshino
Mar 29, 2003·Mechanisms of Ageing and Development·Bart P F RuttenChristoph Schmitz
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Nov 5, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·G AmadoroP Calissano

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