Co-medication and potential drug interactions among patients with epilepsy

Seizure : the Journal of the British Epilepsy Association
Magdalena BosakWojciech Turaj

Abstract

This study aimed to analyze the extent of co-medication and to assess potential interactions between antiepileptic drugs (AEDs) and other drugs among patients with epilepsy. We studied 663 consecutive patients with epilepsy seen in tertiary outpatient clinic. Data on epilepsy and current treatment with AED(s) were collected from structured interview and medical records. Other medications used regularly were classified according to the Anatomical Therapeutic Chemical classification system. Possible drug interactions between AEDs and other drugs were analyzed with the use of IBM Micromedex® database. Studied sample included 395 women; 54.5% of subjects were on monotherapy. Enzyme-inducing AED(s) were used by 127 patients (19.2%). Among 265 patients who used medications other than AEDs (40.0% of all subjects), potential major and moderate interactions between AEDs and other drugs were found in 80 patients (30.1%). Most prevalent major interactions included: ethinylestradiol/estradiol - valproate/oxcarbazepine/carbamazepine, sertraline-carbamazepine, and simvastatin-carbamazepine. A total number of currently used medications (OR = 1.26 [1.07-1.48] per one additional medication; p = 0.005) and the use of enzyme-inducing AEDs (OR = 2...Continue Reading

Citations

May 8, 2019·International Journal of Environmental Research and Public Health·Ying-Chyi ChouKuan-Ming Lai
Aug 1, 2020·JAMIA Open·Anita M PreiningerGretchen Purcell Jackson
Nov 25, 2020·Paediatric Drugs·Gregory L Holmes
May 9, 2021·Epilepsy & Behavior : E&B·Laura KirkpatrickTraci M Kazmerski
Aug 11, 2020·Seizure : the Journal of the British Epilepsy Association·Johanna W BunschotenRoland D Thijs
Dec 19, 2020·Seizure : the Journal of the British Epilepsy Association·Roy G Beran

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